The Impact of Impaired Cerebral Autoregulation on the Development of Postoperative Delirium in Elderly Patients Undergoing Spine Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 99
- 试验地点
- 1
- 主要终点
- Incidence of post-operative delirium in elderly patients undergoing spine surgery at Johns Hopkins Hospital
研究概览
简要总结
Delirium (confusion) after surgery is common and associated with a longer hospitl stay and increased hopsital cost. There is very little information available about how often delirium occurs and the complications associated with it. Elderly patients are at high risk for delirium after surgery. This research is being done to measure how often delirium after spine surgery occurs and to see if there are ways to predict if delirium will develop. The results from this study will provide important information on a possible mechanism and predictor of delirium.
详细描述
Delirium (confusion) after surgery is common and associated with a longer hospitl stay and increased hopsital cost. This research is being done to measure how often delirium after spine surgery occurs and to see if there are ways to predict if delirium will develop. We hypothesize that impaired cerebral autoregulation may be a possible mechanism for postoperative delirium. We will measure intraoperative cerebral autoregulation and assess the relationship with postoperative dleirium. The results from this study will provide important information on a possible mechanism and predictor of delirium.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 70 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •≥ 70 years old,
- •Undergoing any lumbar spine surgery, posterior cervical spine surgery, or anterior cervical spine surgery > 2 levels
排除标准
- •Delirium at baseline
- •Inability to speak and understand English
- •Severe hearing impairment, resulting in inability to converse.
- •Planned use of intraoperative ketamine
- •Planned use of intraoperative remifentanil, except for airway management pre-incision.
- •Arterial catheter not planned to be inserted
结局指标
主要结局
Incidence of post-operative delirium in elderly patients undergoing spine surgery at Johns Hopkins Hospital
时间窗: 24 months
次要结局
- Severity of postoperative delirium, using Delirium Rating Scale-Revised-1998, in elderly patients undergoing spine surgery.(24 months)
研究者
Charles Brown, MD
Principal Investigator
Johns Hopkins University