Influence of a 3-week multidisciplinary inpatient rehabilitation on the AGE/sRAGE-system in patients with Diabetes Mellitus Typ II

Not Applicable

• Conditions: E11; Type 2 diabetes mellitus

• Registration Number: DRKS00018930
• Lead Sponsor: udwig Boltzmann Institut für Arthritis u. Rehabilitation / Department Rehabilitation

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-11-20
• Study Completion: 2021-07-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

age from 25 to 75 years, inpatient rehabilitation, patients with known diabetes mellitus type II

Exclusion Criteria

renal insufficiency Stadium III (Creatinine Clearance < 60 ml/min Cockcroft-Gault), acute inflammatory diseases (CRP cut off > 10 mg/l), operation or trauma < 6 weeks, myocardial infarction < 10 weeks, Pregnancy and lactation, alcohol or drugs

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Estimation of the AGE/sRAGE-ratio at baseline (T1) and the end (T2) of a 3-week lasting multidisciplinary inpatient rehabilitation. AGEs- and sRAGE-levels will determined by ELISA-technique with serum samples of the patients.

Secondary Outcome Measures

Name	Time	Method
Investigation of routine parameters, peroxides, inflammatoric and oxidative markers (ELISA with serum samples), non invasive AGE measurements with fluorescence in the skin, as well as collection of anthropometric data at baseline (T1) and the end (T2) of the inpatient multidisciplinary rehabilitation.