Effect of 12-week Milk Fat Globule Membrane Supplementation on the Human Muscle Function of Middle-aged Exercisers

Not Applicable

Not yet recruiting

• Conditions: Ageing Well; Age-Related Atrophy; Age-Related Sarcopenia

• Registration Number: NCT06573749
• Lead Sponsor: Loughborough University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-8-21
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Not yet recruiting
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

Inclusion Criteria:<br><br> - 45-65 year olds<br><br> - Male or female<br><br> - Healthy with no contraindications to exercise<br><br> - Classified as recreationally active (meet the government's guidelines for weekly<br> physical activity - 150 minutes of moderate physical activity or 75 minutes of<br> vigorous physical activity)<br><br>Exclusion Criteria:<br><br> - Any injury, medical condition or symptom precluding the ability to complete<br> strenuous exercise as identified by the health screen questionnaire and physical<br> activity readiness questionnaire<br><br> - Uncontrolled hypertension (blood pressure of 140/90 mmHg or higher) as identified by<br> recording resting blood pressure<br><br> - Neuromuscular or musculoskeletal disease<br><br> - Occurrence of a severe injury to the lower limbs or back within the previous 6<br> months (time loss of > 21 days of normal activity)<br><br> - Occurrence of a minor injury to the lower limbs or back within the previous month<br> (time loss of >1 day of normal activity)<br><br> - Do not meet the government guidelines of minimum weekly physical activity as<br> revealed by the IPAQ-SF<br><br> - Allergic to dairy or pea, or lactose intolerant<br><br> - Complete greater than 6 hours structured exercise per week as revealed by the<br> exercise and physical activity form<br><br> - Consumption of supplements that may confound the results of the present study within<br> the previous 3 months (includes any form of protein supplement, creatine,<br> pre-workout supplements, any form of testosterone supplement, amino acids,<br> beta-alanine, beta- hydroxy-beta-methylbutyrate (HMB), fish or krill oil, collagen<br> supplements, any choline- containing supplement, or any phospholipid-containing<br> supplement) as highlighted by the health screen questionnaire<br><br> - Taking anticoagulants or antiplatelet drugs<br><br> - Use of antidepressant/anti-anxiety medication<br><br> - Having a blood borne virus, or a partner who has a blood-borne virus<br><br> - Extreme diet classified as identified by the food-frequency questionnaire

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Maximal voluntary isometric torque of the knee extensors

Secondary Outcome Measures

Name	Time	Method
Rate of torque development of the knee extensors;Peak twitch torque (knee extensors);Time to peak twitch torque (knee extensors);Half-relaxation time during twitch contractions (knee extensors);Neural activation of the agonist (quadriceps) and antagonist (hamstrings);Force-frequency relationship of the knee extensors;Neuromuscular junction transmission stability;Cross-sectional area of upper leg muscles;Volume of upper leg muscles;Functional cross-sectional area of upper leg muscles;Functional volume of upper leg muscles;Intramuscular fat infiltration of upper leg muscles;Neuromuscular power;Level of physical activity;Habitual energy intake;Habitual protein intake;Habitual carbohydrate intake;Habitual fibre intake;Habitual fat intake;Habitual choline intake