Identifying neural mechanisms associated with cancer-related fatigue: a cross-sectional study in testicular cancer survivors

Recruiting

• Conditions: kanker-gerelateerde vermoeidheid; 10027946; cancer-related fatigue

• Registration Number: NL-OMON53997
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

For all participants: • Written informed consent • Male • Age between 18 and 50
yrs • Sufficient command of the Dutch language (to answer questionnaires)
For patients: • Unilateral orchiectomy • 3 or 4 cycles of BEP or EP treatment
regimen

Exclusion Criteria

For all participants: • Presence of acute infection or inflammation on day of
testing (body temperature >38) • Current use of prescribed psychotropic, pain
or anti-inflammatory drugs • (history of) long-term (> 6 months) daily use of
over-the-counter NSAIDs (ibuproven, diclofenac, naproxen) (for patients:
besides those used during cancer-treatment) • Current use of over-the-counter
corticosteroids, anti-histamic or anti-inflammatory drugs (participants that
use corticosteroid moistures or hay-fever drugs are asked to not use it on the
testing day) • Obesity (BMI>30) • (history of) metabolic disease (e.g.
diabetes) • (history of) cardiovascular events • (history of) neurological or
psychiatric symptoms/disease • (history of) chronic inflammatory disease (e.g.
rheumatoid arthritis, Crohns disease) • (history of) hypo/hyperthyroide •
(history of) chronic pain (>6 months) (for patients before diagnosis) •
(history of) chronic fatigue syndrome or fibromyalgia (for patients before
diagnosis) • (history of) hypogonadism/ hormonal disturbance or supletion (for
patients before diagnosis) • Metal objects in or around the body •
Claustrophobia • Glaucoma or increased risk for glaucoma • No presence of
metastatic disease or relapse • No patients who received radiotherapy because
other treatment with different side effects

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Task-related activity during effort-based decision making<br /><br>- Self-reported fatigue</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Individual levels of high-sensitive C-reactive protein (CRP) on testing day<br /><br>- Resting-state functional connectivity patterns</p><br>