Effect of Mental Stress on Platelet Function

Not Applicable

Completed

• Conditions: Mental Stress
• Interventions: Behavioral: 2-minute Bondet test

• Registration Number: NCT00538707
• Lead Sponsor: University of Zurich

Brief Summary

The aim of the project is to study the acute and chronic effect of mental stress on platelet adhesion and aggregation in two population composed of normal subjects at different ages

Detailed Description

Psychological stress is an important cardiovascular risk factor. Activation of platelets plays an important role in atherosclerosis development and it could be one of the mechanisms linking psychological stress and cardiovascular diseases.

We plan to include 32 healthy subjects. (16 in every group). One group with subjects at age 20 - 49 and the other group with subjects at age 50 - 70 years.

The aim of the study will be to assess the acute and chronic effect of a standard short mental stress (2-minute Bondet Test) on platelet function and of the level of endothelin-1, catecholamines and cortisol. We plan to evaluate if age may play a role in the effect of psychological stress on platelet function.

Study Timeline

• Study Start: 2007-09
• Study First Submitted: 2007-10-02
• Study First Submitted QC: 2007-10-02
• Study First Posted: 2007-10-03
• Primary Completion: 2009-12
• Study Completion: 2009-12
• Status Verified: 2010-02
• Last Update Submitted: 2010-02-09
• Last Update Posted: 2010-02-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• healthy subjects between 20 - 70 years of age
• written informed consent
• no evidence of diseases

Exclusion Criteria

• pregnancy
• oral contraceptives
• smoking
• use of aspirin or NSAIDs within the last week
• use of benzodiazepines within the last week
• Alcohol or drug abuse
• participation in another study within the last month

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Young subjects	2-minute Bondet test	-
Older subjects	2-minute Bondet test	-

Primary Outcome Measures

Name	Time	Method
Evaluation of platelet function (shear stress dependent platelet adhesion and aggregation) before and after mental stress	60 minutes

Secondary Outcome Measures

Name	Time	Method
Evaluation of the plasma level of endothelin, catecholamines and salivary cortisol level before and after mental stress	60 minutes

Trial Locations

Locations (1)

University Hospital of Zurich; 🇨🇭 Zurich, Switzerland