Effect of Mental Stress on Platelet Function in Healthy Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Evaluation of platelet function (shear stress dependent platelet adhesion and aggregation) before and after mental stress
研究概览
简要总结
The aim of the project is to study the acute and chronic effect of mental stress on platelet adhesion and aggregation in two population composed of normal subjects at different ages
详细描述
Psychological stress is an important cardiovascular risk factor. Activation of platelets plays an important role in atherosclerosis development and it could be one of the mechanisms linking psychological stress and cardiovascular diseases.
We plan to include 32 healthy subjects. (16 in every group). One group with subjects at age 20 - 49 and the other group with subjects at age 50 - 70 years.
The aim of the study will be to assess the acute and chronic effect of a standard short mental stress (2-minute Bondet Test) on platelet function and of the level of endothelin-1, catecholamines and cortisol. We plan to evaluate if age may play a role in the effect of psychological stress on platelet function.
研究设计
- 研究类型
- Interventional
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy subjects between 20 - 70 years of age
- •written informed consent
- •no evidence of diseases
排除标准
- •pregnancy
- •oral contraceptives
- •use of aspirin or NSAIDs within the last week
- •use of benzodiazepines within the last week
- •Alcohol or drug abuse
- •participation in another study within the last month
结局指标
主要结局
Evaluation of platelet function (shear stress dependent platelet adhesion and aggregation) before and after mental stress
时间窗: 60 minutes
次要结局
- Evaluation of the plasma level of endothelin, catecholamines and salivary cortisol level before and after mental stress(60 minutes)