Effect of sedation by propofol and midazolam on cognitive performance

Phase 2

Recruiting

• Conditions: Cognitive disorders following hip surgery under spinal anesthesia.; Senile degeneration of brain, not elsewhere classified; G31.1

• Registration Number: IRCT20120915010841N19
• Lead Sponsor: Hamedan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 26 August 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 136

Inclusion Criteria

Patients older than 65 years
Patients with ASA class 1 and 2
Patients candidate for hip surgery undergoing spinal anesthesia

Exclusion Criteria

Failure to spinal anesthesia and general anesthesia
Patients with history of alcohol and drug use, sedation and anticonvulsants
History sensitivity to anesthetic drugs
History of cognitive impairment
Spinal anesthesia contraindications

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The percentage of people who have Mini Mental State Examination scores less than 20 after spinal anesthesia and taking Propofol or Midazolam. Timepoint: The day before surgery and before discharging from the hospital. Method of measurement: Using Mini Mental State Examination questionnaire.

Secondary Outcome Measures

Name	Time	Method
ausea & vomiting. Timepoint: After surgery. Method of measurement: Observation.;Systolic and Diastolic Blood Pressure. Timepoint: Every three minutes to 20 minutes and then every 10 minutes until the end of the surgery. Method of measurement: Non-invasive automatic barometric device.;Heart Rate. Timepoint: Every three minutes to 20 minutes and then every 10 minutes until the end of the surgery. Method of measurement: Using a pulse oximeter.