Establish a Vegetable Signature Database From Human Metabolomics Responses
- Conditions
- Human Metabolomic Responses to Plant FoodsBlood Pressure
- Registration Number
- NCT01600911
- Lead Sponsor
- National Health Research Institutes, Taiwan
- Brief Summary
Vegetable is well known to prevent chronic disease,however, the mechanism of its nutrients and non-nutrients still remains to be discovered.We design a feeding study which provides plant foods to subjects one by another and monitoring metabolomic changes up to 7 hours.The goal of this study is to establish a protocol for documenting metabolomics response to plant foods and try to characterize plant foods in terms of their anti-hypertension potentials with metabolomic profiling information.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
- Age :18-60 years
- Body Mass Index :18.5-30(kg/m2)
- Non-smoking,alcohol abusing,and other bad hobbies
- With regular drug intake e.g. anti-hypertensive or antidiabetes drug or history of immune, hepatic and metabolic disease or other unsuitable disorders e.g. cancer.
- unwilling to stop regular food supplement e.g. vitamins, herb
- cannot cooperate with designed diet
- History of urinary tract infection or antibiotic use within the previous 3 month
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method blood pressure one day fasting, before lunch,and every 1 hr after lunch
- Secondary Outcome Measures
Name Time Method metabolomic profile of serum and urine one day serum sample will be measure fasting ,before lunch,and every 1 hr after lunch;urine sample will be measure fasting ,before lunch(0hr),0-2 hr,2-4hr 4-7hr after lunch
Trial Locations
- Locations (1)
National Health Research institues, Taiwan
🇨🇳Miaoli County, Taiwan