NCT02271802已完成不适用
Effect of a Butyrate Enema on the Systemic Concentration of Short Chain Fatty Acids
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Plasma SCFAs
研究概览
简要总结
In this placebo-controlled randomized parallel study the effects of a butyrate enema on plasma short-chain fatty acids (SCFA) concentrations and fluxes from portal drained viscera, liver and the splanchnic area are investigated
详细描述
Patients undergoing upper abdominal surgery are included. During surgery they receive a butyrate enema or placebo enema. Before and after rectal administration, plasma samples are taken from several veins and arteries to analyse SCFA concentrations and fluxes from portal drained viscera, liver and the splanchnic area.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing open liver resection or pancreaticoduodenectomy
排除标准
- •known parenchymal liver disease
- •presence of ileostomy or colostomy
- •patients with inflammatory bowel disease
- •antibiotics, prebiotics or probiotics 2 months prior to surgery
研究组 & 干预措施
Placebo
Placebo Comparator
Enema containing NaCl
干预措施: NaCl (Dietary Supplement)
Butyrate
Experimental
Enema containing sodium butyrate
干预措施: Sodium butyrate (Dietary Supplement)
结局指标
主要结局
Plasma SCFAs
时间窗: 0, 5, 15, 30 min after administration
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
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