Role of gut microbiome in epilepsy patients
Not Applicable
- Conditions
- Health Condition 1: G403- Generalized idiopathic epilepsy and epileptic syndromes
- Registration Number
- CTRI/2023/05/052680
- Lead Sponsor
- PGIMER Chandigarh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients with DRE
Age 18 years and above
At least one seizure reported per month
Currently receiving AEDs
Provide Informed Consent
Exclusion Criteria
Time of onset of epilepsy treatment < 2 years prior
Non-epileptic seizures,
Status epilepticus in the last 12 months,
Changes in the AED type or dose in the last 30 days
Active alcohol or substance overuse,
Pregnancy and/or breastfeeding,
Treatment with probiotics in the 30 days before
Chronic gastrointestinal problems, hepatic or renal insufficiency, lactose intolerance, coeliac disease, immunodepression, long-term antibiotic use, a serious psychiatric condition, participating in any other epilepsy-related study
Patients with poor compliance to AEDs
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction in seizure frequency <br/ ><br>Timepoint: 16 weeks
- Secondary Outcome Measures
Name Time Method Gut microbiota analysis <br/ ><br>QOL assessment <br/ ><br>Safety assessmentsTimepoint: 16 weeks