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临床试验/NCT02491814
NCT02491814已完成1 期

The Effect of Commercially-available Dairy and Non-dairy Alternatives When Consumed With a High Glycemic Cereal on Subjective Appetite Ratings and Post-meal Glycemia in Healthy Young Adults

University of Toronto2 个研究点 分布在 1 个国家目标入组 28 人开始时间: 2015年1月最近更新:
适应症

试验速览

阶段
1 期
状态
已完成
入组人数
28
试验地点
2
主要终点
Blood Glucose

研究概览

简要总结

This study investigates the effects of commercially-available dairy (1% cow's milk and yogurt beverage) and non-dairy alternatives (almond and soy beverages) on satiety and post-meal blood glucose. Each participant will receive every treatment in this crossover design study.

详细描述

Regular consumption of dairy is associated with better body composition and lower incidences of type 2 diabetes and obesity. This may be due to dairy's ability to increase satiety and decrease post-prandial glycemia. However, most clinical studies have only investigated isolated dairy proteins (whey and casein) and the effects of whole dairy products remains unclear. Additionally, as non-dairy alternatives are becoming more popular there is interest to see if they can elicit similar benefits as dairy. Therefore, this study will test the effects of commercially-available dairy and non-dairy beverages when consumed with cereal at breakfast time.

Thirty healthy young males and females (20-30 years, BMI 20.0-24.9 kg/m2) will be recruited for the randomized, unblinded, crossover study. Participants will fast overnight, and at baseline will consume 250 mL of 1% milk, soy beverage, almond beverage, yogurt beverage, or water with 54 g of Cheerios cereal. At 0 (baseline), 15, 30, 45, 60, 75, 90, 120 minutes (pre-meal period) 140, and 170 minutes (post-meal period) blood will be collected for glucose analysis and subjective appetite ratings completed. Insulin will be analyzed every 30 minutes and for the last two timepoints. Between 120-140 minutes, an ad libitum lunch will be provided to assess food intake.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
None

入排标准

年龄范围
20 Years 至 30 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Healthy BMI (20.0 - 24.9 kg/m2)
  • Females with regular monthly menstrual cycles

排除标准

  • Fasting blood glucose higher than 5.8 mmol/L
  • Pregnancy
  • Medications
  • Lactose intolerance or allergies to milk, soy, or almonds
  • Elite athletes
  • Those trying to lose or gain weight
  • Breakfast skippers and those on an energy-restricted diet
  • Score equal to or higher than 11 on Eating Habits Questionnaire

结局指标

主要结局

Blood Glucose

时间窗: 0-170 minutes

Blood glucose (mmol/L) is measured using finger prick capillary blood samples

Subjective Appetite

时间窗: 0-170 minutes

Subjective appetite ratings are obtained from four 100 mm visual analogue scale (VAS) questions assessing "Desire to Eat", "Hunger", "Fullness" and "Prospective Food Consumption". The average of all four VAS is calculated to obtain the average appetite score for statistical analysis

次要结局

  • Food Intake(120-140 minutes)
  • Insulin(0-170 minutes)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

G. Harvey Anderson

Professor

University of Toronto

研究点 (2)

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