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Clinical Trials/NCT02994615
NCT02994615
Completed
Not Applicable

Evaluating Microvascular Dysfunction in Symptomatic Patients With HypertroPhic CaRdiomyopathy: The Index of MicrovAscular Resistance (IMR)

Lawson Health Research Institute1 site in 1 country19 target enrollmentStarted: January 2017Last updated:
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ConditionsHypertrophic Cardiomyopathy

Overview

Phase
Not Applicable
Status
Completed
Enrollment
19
Locations
1
Primary Endpoint
IMR in patients with hypertrophic cardiomyopathy (HCM) versus controls
OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Overview

Brief Summary

Patients with hypertrophic cardiomyopathy are being compared to a control group. IMR will be assessed with a pressure wire. Clinical f/u at 3 months and 6 months and a 48 hour holter monitor.

Study Design

Study Type
Observational
Observational Model
Case Control
Time Perspective
Prospective

Eligibility Criteria

Ages
18 Years to 80 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Age 18-80
  • •Already have an indication for coronary angiography
  • •Previous diagnosis of hypertrophic cardiomyopathy (unless control)

Exclusion Criteria

  • •Fractional flow reserve found to be significant (FFR \< 0.8)
  • •Already have a condition associated with or likely to be associated with an elevated IMR (diabetes, cardiac syndrome X, takotsubo cardiomyopathy, hypertensive cardiomyopathy, severe aortic stenosis, STEMI)

Outcomes

Primary Outcomes

IMR in patients with hypertrophic cardiomyopathy (HCM) versus controls

Time Frame: 1 day

Secondary Outcomes

  • Number of ventricular tachycardia(6 months)
  • Shortness of breath - NYHA class(Up to 6 months)
  • Chest pain - Canadian Cardiovascular Society (CCS) class(Up to 6 months)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Shahar Lavi

Director of Cardiovascular Interventional Research

Lawson Health Research Institute

Study Sites (1)

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