Movement Dynamics of Knee Osteoarthritis and Total Knee Replacement

Recruiting

• Conditions: Knee Osteoarthritis; Total Knee Replacement

• Registration Number: NCT06829433
• Lead Sponsor: University of Portsmouth

Brief Summary

This research aims to explore differences in walking and functional movement mechanics, exercise response, and physical activity between people with osteoarthritis (OA), those who have undergone total joint replacement, and healthy individuals.

Detailed Description

People living with OA tend to be less physically active than those without the disease, which is often due to pain, stiffness and joint instability. This reduction in physical activity can lead to additional health problems down the line. When the disease becomes severe, joint replacement surgeries are sometimes performed to relieve pain and improve individuals' quality of life. However, despite reducing pain, there is little evidence to show that joint replacement surgeries encourage individuals to return to healthy physical activity levels.

Reasons for the lack of change may include a failure to address unhealthy walking and movement patterns which could still be causing pain and instability and reduced physical fitness levels.

By investigating these reasons, we hope that findings from this study will help to inform future interventions that improve clinical outcomes and quality of life for individuals with OA and post-joint replacement.

Study Timeline

• Study Start: 2024-05-07
• Study First Submitted: 2025-01-28
• Status Verified: 2025-02
• Study First Submitted QC: 2025-02-10
• Study First Posted: 2025-02-17
• Last Update Submitted: 2025-02-19
• Last Update Posted: 2025-02-21
• Primary Completion: 2026-01
• Study Completion: 2026-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Diagnosed symptomatic bilateral or unilateral knee osteoarthritis, self-reported ability to walk without an aid for 10 minutes and to ascend and descend stairs, no neurological conditions or other musculoskeletal pathology/injury which would impact walking gait.

Exclusion Criteria

• Unable to walk at 0.8 m/s, exclusion based on IMO screening, non-English speaking, lacking ability to consent.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Peak knee adduction moment	From the start of a biomechanical movement testing visit to the end (approximately 2 hours)	The external knee adduction moment (KAM), which reflects medial-to-lateral knee joint load distribution during gait, has become an OA treatment target. The peak KAM is a strong predictor of presence, severity, and the rate of progression of knee OA.

Trial Locations

Locations (1)

School of Psychology, Health and Sport Sciences, University of Portsmouth; 🇬🇧 Portsmouth, Hampshire, United Kingdom