Biomarkers in Concussion
Not yet recruiting
- Conditions
- Concussion, SevereConcussion, MildConcussion, Intermediate
- Registration Number
- NCT05943561
- Lead Sponsor
- Medstar Health Research Institute
- Brief Summary
This will be an observational study measuring serum Neurofilament Light Chain concentrations and associated symptoms, with a control branch, and a post-concussion branch.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Over 12 years of age Athletes participating on a sports team willing to participate; undergo blood draws either weekly or every two weeks, depending on arm of study.
Exclusion criteria:
Existing active neurodegenerative disorder (ie severe TBI) Active peripheral nerve disorder (ie diabetic neuropathy)
Exclusion Criteria
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Normalization of NfL levels 12 weeks
- Secondary Outcome Measures
Name Time Method Resolution of concussion symptoms 12 weeks
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What role does serum Neurofilament Light Chain (NfL) play in axonal injury detection after mild, intermediate, and severe concussions?
How does serum NfL concentration correlate with symptom severity and recovery timelines in post-concussion patients compared to controls?
Which molecular pathways are associated with Neurofilament Light Chain elevation in traumatic brain injury subtypes like concussions?
What are the potential adverse events linked to elevated NfL levels in concussion patients, and how are they managed clinically?
How do serum NfL biomarkers compare to other TBI indicators like S100B or Tau protein in predicting long-term outcomes for concussion severity subtypes?