NCT02629705已完成不适用
Investigation of the Effect of Carrageenan as Food Additive on Insulin Resistance in Humans
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Insulin sensitivity assessed by hyperinsulinemic clamp: M-value
研究概览
简要总结
The purpose of this study is to determine whether the ingestion of the common food additive carrageenan contributes to insulin resistance and thus to the pathogenesis of type 2 diabetes in humans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •body mass index (BMI) 18.5 - 29.9 kg/m²
排除标准
- •any chronic illness
- •any ongoing medication
- •known infections
- •known liver disease
- •known renal insufficiency
- •alcohol consumption over 30 g/d
- •shift work
结局指标
主要结局
Insulin sensitivity assessed by hyperinsulinemic clamp: M-value
时间窗: 2 weeks
Insulin sensitivity assessed by oral glucose tolerance test (OGTT): Matsuda index
时间窗: 2 weeks
次要结局
- Endogenous glucose production measured by tracer-method(2 weeks)
- Cerebral insulin sensitivity measured by MRI(2 weeks)
- Intrahepatic triglyceride content(2 weeks)
- Glycemia during OGTT(2 weeks)
研究者
研究点 (2)
Loading locations...
相似试验
招募中
不适用
Investigating the Impact of the Seaweed Derived Food Additive, Carrageenan, on the Human Gut MicrobiomeGut MicrobiomeHealthy DonorsNCT06738329University of Reading99
已完成
Unknown
Study of the effects of ingestion of food ingredients on skin elasticity (SWE-2022-06- HCRINK)ot applicableJPRN-UMIN000049796Suntory Wellness Limited120
已完成
1 期
The Effect of Food on the Pharmacokinetic Characteristics of CKD-501HealthyNCT01071720Chong Kun Dang Pharmaceutical24
已完成
Unknown
Investigation of the effects by ingesting the food containing the lactic acid bacteria on gut environmentHealthy male/female adultsJPRN-UMIN000049791Metagen, Inc.40
已完成
不适用
A study of the effect of food ingredient on cognitive function. (SIC-2019-07-SHKBSN)ot applicableJPRN-UMIN000038593Hokkaido Information University80