Schema-ECT
Suspended
- Conditions
- Depression, ECT, reconsolidation
- Registration Number
- NL-OMON26071
- Lead Sponsor
- Academic Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Suspended
- Sex
- Not specified
- Target Recruitment
- 98
Inclusion Criteria
•Diagnosis of major depressive disorder (MDD) without psychotic symptoms assessed with the Mini Neuropsychiatric Interview (MINI)
•Clinical indication for ECT
•18-70 years of age
•Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements
Exclusion Criteria
•Bipolar disorder, schizophrenia, primary alcohol or drug abuse, or any cognitive disorder as assessed with the Mini Neuropsychiatric Interview (MINI)
•Patients with MR contraindications such as metal implants or claustrophobia will be excluded from the neuroimaging study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method •Hamilton Rating Scale for Depression (HAM-D) scores<br>•Time to relapse/recurrence
- Secondary Outcome Measures
Name Time Method •Hippocampal magnetic resonance spectroscopy (MRS)<br>•Structural connectivity using diffusion tensor imaging (DTI)<br>•Functional connectivity using functional magnetic resonance imaging (fMRI)<br>•Biomarker levels determined from blood samples<br>