Personalising Dosing Strategy for Amblyopia Treatment

Not Applicable

Completed

• Conditions: Topic: Eye, Generic Health Relevance and Cross Cutting Themes; Subtopic: Eye (all Subtopics), Generic Health Relevance (all Subtopics); Disease: Ophthalmology, Paediatrics; Eye Diseases; Amblyopia ex anopsia

• Registration Number: ISRCTN12292232
• Lead Sponsor: City University London (UK)

Brief Summary

2015 protocol in: http://www.ncbi.nlm.nih.gov/pubmed/25906974

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-12-17
• Study Completion: 2015-03-01
• Last Update Posted: 6 July 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

1. The trial will recruit subjects with amblyopia associated with:
1.1. Strabismus
1.2. Anisometropia
1.3. A combination of anisometropia and strabismus
2. Children aged between 3 and 8 years with visual acuity of 0.2 logMAR or lower in the worst eye and an inter-ocular difference of at least 0.2 log units with the presence of anisometropia and/or strabismus and no other ocular pathology including amblyopia associated with form deprivation or previous occlusion treatment history will be eligible for recruitment.
3. Target Gender: Male & Female

Exclusion Criteria

1. Those with other ocular pathology
2. Those with form deprivation amblyopia as this is a minority group and often is linked with other ocular pathology
3. Previous history of treatment for amblyopia
4. Those with learning difficulties and therefore cannot perform an accurate visual acuity test on every occasion tested

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Visual acuity change; Timepoint(s): Change in visual acuity of the amblyopic eye during treatment

Secondary Outcome Measures

Name	Time	Method
The secondary outcome measure will be stereoacuity measured using the Frisby test and the Randot pre-schooler test