Cannabinoid CB1 Receptors in Human Brown Adipose Tissue
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- CB1 density of brown adipose tissue acquired with PET
研究概览
简要总结
This study investigates cannabinoid CB1 receptors in human brown adipose tissue (BAT) and other tissues using positron emission tomography (PET) imaging. Subjects will be scanned in room temperature conditions and during controlled cold exposure, and the density of CB1 receptors in BAT and other tissues will be quantified. The investigators hypothesize, that cannabinoid signaling is increased in cold conditions, when BAT is metabolically active.
Understanding the mechanisms of BAT activation and the role of endocannabinoids in humans is important and beneficial in fighting against the epidemic of obesity and diabetes.
详细描述
Endocannabinoids have an important role in regulating energy balance and metabolism. Cannabinoid 1 receptors (CB1) are found in several tissues such as brown adipose tissue (BAT). Endocannabinoids and CB1 receptors participate in the control of lipid and glucose metabolism, and blockage of CB1 receptors has been found to improve metabolic factors linked to obesity and cardiovascular disease, making CB1 antagonists potential drugs against obesity and diabetes.
In this study the investigators use a PET radiotracer [18F]FMPEP-d2, which binds to CB1 receptors in vivo, to quantify the CB1 receptor density in BAT, white adipose tissue, muscle and the brain. This study is done once in warm conditions and once during controlled cold exposure. To verify whether the subject has metabolically active BAT, an additional PET scan with the radiotracer [18F]FDG is performed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteer
- •Group 1: BMI 20-26 kg/m2, Group2: BMI 27-40 kg/m2
排除标准
- •BMI < 20 kg/m2or BMI > 40 kg/m2
- •Any chronic disease that could affect the study outcome, including medicated type 2 diabetes
- •Mental disorder or poor compliance
- •Eating disorder or excessive use of alcohol, tobacco smoking or drug use
- •Past dose of radiation
- •Presence of any ferromagnetic objects that would make MR imaging contraindicated
- •Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
结局指标
主要结局
CB1 density of brown adipose tissue acquired with PET
时间窗: within one study day
PET imaging is used to quantify CB1 receptors in tissues
次要结局
- Glucose uptake of brown adipose tissue acquired with PET(within one study day)
研究者
Pirjo Nuutila
Professor
Turku University Hospital