Coagulation disorders in trauma patients

Completed

• Conditions: Traumatisch letsel; accidental injury; Traumatic injury

• Registration Number: NL-OMON33294
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 120

Inclusion Criteria

Trauma patients treated by a trauma team that received medical care in the shock room
Age > 18 years

Exclusion Criteria

Patients with haemostatic abnormalities or deficiencies

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The incidence proportion of bleeding in trauma patients as reflected by blood<br /><br>transfusions and/or surgical- or radiological interventions to control<br /><br>bleeding.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* Level of comparison of INTEM clotting time and aPTT and FIBTEM and Clauss<br /><br>test for fibrinogen.<br /><br>* Age, gender, length, body weight, hematocrit, hemoglobin, leukocyte count,<br /><br>CRP, highest creatinine, ISS, predictive outcome scores<br /><br>* Temperature upon arrival at the emergency department and temperature dynamics<br /><br>over the first 24 hours post-trauma.<br /><br>* Level of fibrinolysis using ROTEM APTEM test<br /><br>* Tissue factor, thrombin, thrombin-antithrombin complexes (TAT), antithrombin<br /><br>III (AT III), D-dimers and protein C<br /><br>* Medicine use: use of drugs that influence coagulation<br /><br>* Administration of blood products and fluid, urine production</p><br>