Acute coagulopathy and inflammation of trauma-3
- Conditions
- clotting disordercoagulopathy100644771002211410038716
- Registration Number
- NL-OMON42991
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 500
Age > 18 years
Sustained a blunt or penetrating trauma, with at least one of the following clinical parameters:
o Reparatory rate <10 or >25 times per minute
o Heart rate *120 per minute
o Systolic blood pressure < 90 mmHg
o Oxygen saturation <90%
o Estimated blood loss *500 mL
o GCS * 13 or abnormal pupil size and/or reaction
* Or clinical signs of at least one of the following diagnoses:
o 1 femur fracture
o Signs of flail thorax/pneumothorax/hematothorax or multiple rib fractures
o Signs of significant abdominal injury
o Pelvic fracture
o Spine injury
Age <18
Patients transferred from other hospitals
Patients presenting more than 120 minutes after time of injury
Patients who have received more than 2000 mL of intravenous fluids prior to emergency department arrival
Patients with burns >5% of their body surface area
Patients taking anticoagulant medication other than aspirin (<650mg/day)
Patients with a known bleeding diathesis
Patients with moderate to severe liver disease (Child's classification B or C)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>28 day mortality </p><br>
- Secondary Outcome Measures
Name Time Method <p>Blood transfusion requirement in first 24 hours, length of hospital stay, ICU<br /><br>stay, 28-day ventilator free days, occurrence of acute lung injury (ALI), acute<br /><br>respiratory distress syndrome (ARDS), acute kidney injury (AKI) and multiple<br /><br>organ failure (MOF) </p><br>