Infuence of the day-night rhythm on renal clearance of tobramycin in cystic fibrosis patients.
Recruiting
- Conditions
- cystic fibrosiscystische fibrosekidney damagenierschade
- Registration Number
- NL-OMON25851
- Lead Sponsor
- Haga Medical Center, The Hague
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 22
Inclusion Criteria
1. Age: ≥ 18 years;
2. A diagnosis of cystic fibrosis (ie, sweat chloride ≥ 60 mmol/L or a genotype associated with cystic fibrosis);
Exclusion Criteria
1. Use of nephrotoxic drugs (NSAID´s, furosemide, vancomycin);
2. Allergy for aminoglycosides;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the renal clearance of tobramycin in CF patients receiving a daily intravenous dose in the morning against patients receiving a daily intravenous dose of tobramycin in the evening.
- Secondary Outcome Measures
Name Time Method To compare biochemical parameters of kidney function in patients who receive a dose of tobramycin in the morning against patients who receive a dose of tobramycin in the evening.