A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205
- Registration Number
- NCT04241068
- Lead Sponsor
- Biogen
- Brief Summary
The primary objective is to evaluate the safety and tolerability of aducanumab over 100 weeks of treatment after a wash-out period imposed by discontinuation of feeder studies in participants who had previously received aducanumab (i.e. previously treated participants) or who had previously received placebo (i.e. treatment-naïve participants).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 1696
Core Treatment Period:
- Participant was participating in an aducanumab clinical study at the time of the announcement of early termination (feeder studies).
- Has one care partner who, in the Investigator's opinion, has adequate contact with the participant as to be able to provide accurate information about the participant's cognitive and functional abilities.
LTE Treatment Period:
- Participant must have completed the Core study period (Week 102) and adequately tolerated 10 mg/kg of aducanumab during the Core study period in the opinion of the Investigator.
- Has one informant/care partner who, in the Investigator's opinion, has frequent and sufficient contact with the participant as to be able to provide accurate information about the participant's cognitive and functional abilities.
Key
Core Treatment Period:
- Any medical or neurological condition (other than Alzheimer's Disease) that might be a contributing cause of the participant's cognitive impairment.
- Stroke or any unexplained loss of consciousness within 1 year prior to Screening.
- Clinically significant unstable psychiatric illness in past 6 months.
- History of unstable angina, myocardial infarction, advanced chronic heart failure, or clinically significant conduction abnormalities within 1 year prior to Screening.
- A seizure event that occurred after the last visit of the feeder study and before Screening for this study.
- Evidence of impaired liver function as shown by an abnormal liver function profile at Screening.
- History of or known seropositivity for HIV.
- Clinically significant systemic illness or serious infection within 30 days prior to or during Screening.
- Contraindications to having a brain magnetic resonance imaging (MRI).
LTE Treatment Period:
- Any medical or psychiatric contraindication or clinically significant abnormality that, in the opinion of the Investigator, will substantially increase the risk associated with the participant's enrollment in and completion of the study.
Note- Other protocol defined Inclusion/Exclusion criteria may apply.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Aducanumab Aducanumab Participants will be administered aducanumab 10 milligrams per kilogram (mg/kg) by intravenous (IV) infusions every four weeks (Q4W) for a duration of 100 weeks during the Core Treatment Period. Eligible participants will continue to receive aducanumab 10 mg/kg IV infusion, Q4W, for 52 weeks during the Long-Term Extension (LTE) Treatment Period.
- Primary Outcome Measures
Name Time Method Core Treatment Period: Number of Participants With Treatment-Emergent Adverse Events (TEAEs) and Serious TEAEs From the first dose of study drug to end of follow-up (up to Week 118) An AE is any untoward medical occurrence in a participant/clinical investigation participant administered a pharmaceutical product and that does not necessarily have a causal relationship with this treatment. An AE can be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease temporally associated with use of medicinal(investigational) product, whether or not related to medicinal (investigational) product. An SAE is any untoward medical occurrence that at any dose results in death, is a life-threatening event, requires inpatient hospitalization or prolongation of existing hospitalization, results in significant disability/incapacity or congenital anomaly, is medically important event. TEAE or Serious TEAEs are defined as any AE that has an onset date and time that is on or after date and time of first dose of study treatment, or that has worsened after date and time of first dose of study treatment.
Core Treatment Period: Number of Participants With AEs Leading to Treatment Discontinuation (TD) and Study Withdrawal (SW) From the first dose of study drug to end of follow-up (up to Week 118) An AE is any untoward medical occurrence in a participant or clinical investigation participant administered a pharmaceutical product and that does not necessarily have a causal relationship with this treatment. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease temporally associated with the use of a medicinal (investigational) product, whether or not related to the medicinal (investigational) product.
Core Treatment Period: Number of Participants With Amyloid-Related Imaging Abnormality-Edema (ARIA-E) Up to Week 118 Number of participants diagnosed with ARIA edema are reported.
Core Treatment Period: Number of Participants With Positive Antidrug Antibodies (ADAs) in Serum Up to Week 102 The presence of serum ADAs was determined using a validated assay. A standard 3-tiered approach was used including screening assay, confirmatory assay, and titration assay. The number of participants with a positive response to ADAs are reported.
Core Treatment Period: Number of Participants With Amyloid-Related Imaging Abnormality- Hemorrhage or Superficial Siderosis (ARIA-H) Up to Week 118 Number of participants diagnosed with ARIA hemmorrhage or superficial siderosis are reported.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (259)
Montreal Neurological Institute Clinical Research Unit
🇨🇦Montréal, Quebec, Canada
CHU Lille - Hopital Roger Salengro
🇫🇷Lille Cedex, Nord, France
Hôpital Lariboisière
🇫🇷Paris cedex 10, Paris, France
Hôpital des Chapennes
🇫🇷Villeurbanne, Rhone, France
mind mvz GmbH
🇩🇪Stuttgart, Baden Wuerttemberg, Germany
Institut fuer Schlaganfall- und Demenzforschung (ISD)
🇩🇪München, Bayern, Germany
Neuropraxis Muenchen Sued
🇩🇪Unterhaching, Bayern, Germany
Charite Universitaetsmedizin Berlin - Campus Berlin Buch
🇩🇪Berlin, Germany
Neuro Centrum Science GmbH, Geschaftführende Gesellschafterin Barbara Unsorg und Prüfarzt Dr. med. G
🇩🇪Erbach, Hessen, Germany
Zentrum f. Neurologisch- Psychiatrische Studien und Begutachtung
🇩🇪Siegen, Nordrhein Westfalen, Germany
University of Miami
🇺🇸Miami, Florida, United States
Miami Jewish Health System, Inc
🇺🇸Miami, Florida, United States
CCBR - Vejle - DK
🇩🇰Vejle, Denmark
University of California San Diego Medical Center
🇺🇸La Jolla, California, United States
USC Keck School of Medicine
🇺🇸Los Angeles, California, United States
Neurology Center of North Orange County
🇺🇸Fullerton, California, United States
California Neuroscience Research Medical Group Inc.
🇺🇸Sherman Oaks, California, United States
Josephson, Wallack, Munshower Neurology, P.C.
🇺🇸Indianapolis, Indiana, United States
Yale University
🇺🇸Fairfield, Connecticut, United States
JEM Research
🇺🇸Atlantis, Florida, United States
Renstar Medical Research
🇺🇸Ocala, Florida, United States
Alexian Brothers Medical Center - Neuroscience Research Institute
🇺🇸Elk Grove Village, Illinois, United States
Premiere Research Institute
🇺🇸West Palm Beach, Florida, United States
Senior Clinical Trials, Inc.
🇺🇸Laguna Hills, California, United States
Bradenton Research Center, Inc
🇺🇸Bradenton, Florida, United States
Palm Beach Neurological Center
🇺🇸Palm Beach Gardens, Florida, United States
ActivMed Practices & Research, Inc.
🇺🇸Portsmouth, New Hampshire, United States
Advocate Lutheran General Hospital
🇺🇸Park Ridge, Illinois, United States
Lehigh Center for Clinical Research, LLC
🇺🇸Allentown, Pennsylvania, United States
IMMUNOe International Research Centers
🇺🇸Centennial, Colorado, United States
Quantum Laboratories Inc.
🇺🇸Pompano Beach, Florida, United States
Donald S. Marks, M.D., P.C.
🇺🇸Plymouth, Massachusetts, United States
Mount Sinai School of Medicine
🇺🇸New York, New York, United States
Emory University Cognitive Neurology Clinic & ADRC
🇺🇸Atlanta, Georgia, United States
Indiana University School of Medicine
🇺🇸Indianapolis, Indiana, United States
Mayo Clinic in Florida
🇺🇸Jacksonville, Florida, United States
Neuropsychiatric Research Center of Southwest Florida
🇺🇸Fort Myers, Florida, United States
Penn Memory Center
🇺🇸Philadelphia, Pennsylvania, United States
Brigham and Women's Hospital Department of Neurology
🇺🇸Boston, Massachusetts, United States
Mayo Clinic
🇺🇸Rochester, Michigan, United States
AMC Research, LLC
🇺🇸Charlotte, North Carolina, United States
New York University Medical Center PRIME
🇺🇸New York, New York, United States
Raleigh Neurology Associates
🇺🇸Raleigh, North Carolina, United States
Cleveland Clinic Foundation
🇺🇸Cleveland, Ohio, United States
Boston Center for Memory
🇺🇸Newton, Massachusetts, United States
McLean Hospital
🇺🇸Belmont, Massachusetts, United States
Empire Neurology, PC
🇺🇸Latham, New York, United States
The Clinical Trial Center, LLC
🇺🇸Jenkintown, Pennsylvania, United States
University of Pittsburgh
🇺🇸Pittsburgh, Pennsylvania, United States
Clinical Trial Network
🇺🇸Houston, Texas, United States
Advanced Memory Research Inst. of NJ, PC
🇺🇸Toms River, New Jersey, United States
Neurology Clinic, PC
🇺🇸Cordova, Tennessee, United States
Butler Hospital
🇺🇸Providence, Rhode Island, United States
UT Southwestern Medical Center
🇺🇸Dallas, Texas, United States
Christian-Doppler-Klinik - Universitätsklinikum Salzburg
🇦🇹Salzburg, Austria
CHU Reims - Hôpital Maison Blanche
🇫🇷Reims, Marne, France
CHU de Lyon - Hopital Neurologique Pierre Wertheimer
🇫🇷Bron Cedex, Rhone, France
Hôpital Broca
🇫🇷Paris, France
Neurologie im Tempelhofer Hafen
🇩🇪Berlin, Germany
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
🇮🇹Brescia, Italy
Neurologische Gemeinschaftspraxis Kassel
🇩🇪Kassel, Hessen, Germany
Erasmus Medisch Centrum
🇳🇱Rotterdam, Netherlands
Novo-Med Zielinski i wspolnicy Sp. j.
🇵🇱Katowice, Poland
Konkuk University Medical Center
🇰🇷Seoul, Korea, Republic of
Inha University Hospital
🇰🇷Incheon, Gyeonggi-do, Korea, Republic of
Policlinica Gipuzkoa
🇪🇸San Sebastian, Guipuzcoa, Spain
PALLMED Sp. z o.o.
🇵🇱Bydgoszcz, Poland
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Spain
Fundacio ACE
🇪🇸Barcelona, Spain
Hospital Universitari i Politecnic La Fe
🇪🇸Valencia, Spain
Kaohsiung Chang Gung Memorial Hospital
🇨🇳Kaohsiung, Taiwan
Newcastle University
🇬🇧Newcastle upon Tyne, Tyne & Wear, United Kingdom
Ninewells Hospital
🇬🇧Dundee, Tayside Region, United Kingdom
A.O.U. Senese Policlinico Santa Maria alle Scotte
🇮🇹Siena, Italy
Pacific Research Network, Inc
🇺🇸San Diego, California, United States
Las Vegas Medical Research
🇺🇸Las Vegas, Nevada, United States
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Republic of
Complejo Hospitalario Ruber Juan Bravo
🇪🇸Madrid, Spain
Center for Neurosciences
🇺🇸Tucson, Arizona, United States
Hattiesburg Clinic, PA
🇺🇸Hattiesburg, Mississippi, United States
Azienda Ospedaliera Card. G. Panico
🇮🇹Tricase, Lecce, Italy
SPZOZ Centralny Szpital Kliniczny UM w Lodzi
🇵🇱Lodz, Poland
Research Site
🇯🇵Yamagata-shi, Yamagata-Ken, Japan
Centrum Medyczne Senior
🇵🇱Sopot, Poland
Hôpital de la Timone
🇫🇷Marseille cedex 05, Bouches-du-Rhône, France
Ascension Via Christi Research, a division of Ascension Via Christi Hospitals Wichita, Inc.
🇺🇸Wichita, Kansas, United States
University of Kansas Medical Center Research Institute, Inc.
🇺🇸Fairway, Kansas, United States
UCSF - Memory and Aging Center
🇺🇸San Francisco, California, United States
Albany Medical College
🇺🇸Albany, New York, United States
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
Lynn Health Science Institute
🇺🇸Oklahoma City, Oklahoma, United States
CHU Strasbourg - Hôpital Hautepierre
🇫🇷Strasbourg Cedex, Bas Rhin, France
Medical Research Health and Education Foundation, Inc
🇺🇸Columbus, Georgia, United States
KaRa Institute of Neurological Diseases
🇦🇺Macquarie Park, New South Wales, Australia
The Medical Arts Health Research Group
🇨🇦Penticton, British Columbia, Canada
Cleveland Clinic Florida - Weston
🇺🇸Weston, Florida, United States
Axiom Clinical Research of Florida
🇺🇸Tampa, Florida, United States
Stedman Clinical Trials, LLC
🇺🇸Tampa, Florida, United States
USF Health Byrd Institute
🇺🇸Tampa, Florida, United States
Meridien Research
🇺🇸Tampa, Florida, United States
Institut et Clinique MoCA
🇨🇦Greenfield Park, Quebec, Canada
Toronto Sunnybrook Hospital
🇨🇦Toronto, Ontario, Canada
Toronto Western Hospital
🇨🇦Toronto, Ontario, Canada
Brain Research Center
🇳🇱Amsterdam, Netherlands
Karolinska Universitetssjukhuset, Huddinge
🇸🇪Stockholm, Sweden
Osrodek Badan Klinicznych EUROMEDIS
🇵🇱Szczecin, Poland
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
UCI MIND
🇺🇸Irvine, California, United States
Mary S. Easton Center for Alzheimer's Disease Research, UCLA
🇺🇸Los Angeles, California, United States
Pacific Neuroscience Medical Group
🇺🇸Oxnard, California, United States
University of Colorado Denver
🇺🇸Aurora, Colorado, United States
Anderson Clinical Research
🇺🇸Redlands, California, United States
Stanford Hospital and Clinics
🇺🇸Palo Alto, California, United States
Syrentis Clinical Research
🇺🇸Santa Ana, California, United States
Research Center for Clinical Studies, Inc.
🇺🇸Norwalk, Connecticut, United States
Brain Matters Research
🇺🇸Delray Beach, Florida, United States
Jacksonville Center for Clinical Research
🇺🇸Jacksonville, Florida, United States
Infinity Clinical Research, LLC
🇺🇸Hollywood, Florida, United States
NeuroStudies.net, LLC
🇺🇸Decatur, Georgia, United States
Fort Wayne Neurological Center
🇺🇸Fort Wayne, Indiana, United States
Baptist Health Lexington
🇺🇸Lexington, Kentucky, United States
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States
Cleveland Clinic Lou Ruvo Center for Brain Health
🇺🇸Las Vegas, Nevada, United States
Washington University
🇺🇸Saint Louis, Missouri, United States
University of Rochester
🇺🇸Rochester, New York, United States
Weill Cornell Medical College (WCMC) - Judith Jaffe Multiple Sclerosis Center (JJMSC)
🇺🇸New York, New York, United States
Ohio State University Wexner Medical Center
🇺🇸Columbus, Ohio, United States
Northeastern Pennsylvania Memory and Alzheimer's Center
🇺🇸Wilkes-Barre, Pennsylvania, United States
Rhode Island Mood & Memory Research Institute
🇺🇸East Providence, Rhode Island, United States
Baylor College of Medicine
🇺🇸Houston, Texas, United States
University of Utah Health Sciences Center
🇺🇸Salt Lake City, Utah, United States
The Memory Clinic
🇺🇸Bennington, Vermont, United States
University of Washington Medical Centre
🇺🇸Seattle, Washington, United States
Kingfisher Cooperative, LLC
🇺🇸Spokane, Washington, United States
Medical College of Wisconsin, Inc.
🇺🇸Milwaukee, Wisconsin, United States
The Prince Charles Hospital
🇦🇺Chermside, New South Wales, Australia
St Vincent's Hospital Sydney
🇦🇺Darlinghurst, New South Wales, Australia
Central Coast Neurosciences Research (Erina)
🇦🇺Erina, New South Wales, Australia
Box Hill Hospital
🇦🇺Box Hill, Victoria, Australia
Austin Health
🇦🇺Heidelberg West, Victoria, Australia
Australian Alzheimer's Research Foundation
🇦🇺Nedlands, Western Australia, Australia
Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
LKH - Universitaetsklinikum Graz
🇦🇹Graz, Austria
AKH - Medizinische Universität Wien
🇦🇹Vienna, Austria
AZ Klina
🇧🇪Brasschaat, Belgium
Universitair Ziekenhuis Brussel
🇧🇪Brussel, Belgium
AZ Sint-Jan
🇧🇪Brugge, Belgium
Universitair Ziekenhuis Gent
🇧🇪Gent, Belgium
AZ Groeninge
🇧🇪Kortrijk, Belgium
UZ Leuven
🇧🇪Leuven, Belgium
University of Calgary - Heritage Medical Research Clinic
🇨🇦Calgary, Alberta, Canada
AZ Delta
🇧🇪Roeselare, Belgium
UBC Hospital
🇨🇦Vancouver, British Columbia, Canada
True North Clinical Research - Halifax Inc.
🇨🇦Halifax, Nova Scotia, Canada
Medical Arts Health Research Group
🇨🇦West Vancouver, British Columbia, Canada
True North Clinical Research
🇨🇦Kentville, Nova Scotia, Canada
St. Joseph's HC- Parkwood Institute
🇨🇦London, Ontario, Canada
Bruyere Continuing Care
🇨🇦Ottawa, Ontario, Canada
Kawartha Centre - Redefining Healthy Aging
🇨🇦Peterborough, Ontario, Canada
Toronto Memory Program (Neurology Research Inc.)
🇨🇦Toronto, Ontario, Canada
Clinique de la Memoire de l'Outaouais
🇨🇦Gatineau, Quebec, Canada
CHU de Quebec - Hôpital de l' Enfant Jésus
🇨🇦Quebec, Canada
CCBR - Ålborg - DK
🇩🇰Aalborg, Denmark
Danish Dementia Research Centre
🇩🇰København, Denmark
Terveystalo Ruoholahti
🇫🇮Helsinki, Finland
Itä-Suomen yliopisto, Aivotutkimusyksikkö
🇫🇮Kuopio, Finland
CRST, Clinical Research Services Turku
🇫🇮Turku, Finland
Groupe Hospitalier Pellegrin - Hôpital Pellegrin
🇫🇷Bordeaux Cedex, Gironde, France
Hôpital La Grave
🇫🇷Toulouse Cedex 9, Haute Garonne, France
Hopital Purpan
🇫🇷Toulouse cedex 9, Haute Garonne, France
Hopital Gui de Chauliac
🇫🇷Montpellier, Herault, France
CHU Rennes - Pontchaillou
🇫🇷Rennes cedex 9, Ille Et Vilaine, France
CHU Nantes - Hopital Nord Laënnec
🇫🇷Nantes cedex 1, Loire Atlantique, France
Studienzentrum fur Neurologie und Psychiatrie
🇩🇪Böblingen, Baden Wuerttemberg, Germany
Groupe Hospitalier Pitie-Salpetriere
🇫🇷Paris, France
ISPG - Institut fuer Studien zur Psychischen Gesundheit
🇩🇪Mannheim, Baden Wuerttemberg, Germany
Neuropoint Studienzentrum
🇩🇪Ulm, Baden Wuerttemberg, Germany
Universitaetsklinikum Ulm
🇩🇪Ulm, Baden Wuerttemberg, Germany
Klinikum Bayreuth GmbH- Hohe Warte
🇩🇪Bayreuth, Bayern, Germany
Bezirkskrankenhaus Guenzburg
🇩🇪Günzburg, Bayern, Germany
Klinikum rechts der Isar der TU Muenchen
🇩🇪Munich, Bayern, Germany
Universitaetsklinikum Aachen AOeR
🇩🇪Aachen, Nordrhein Westfalen, Germany
Klinische Forschung Hannover-Mitte GmbH
🇩🇪Hannover, Niedersachsen, Germany
Neurozentrum Bielefeld
🇩🇪Bielefeld, Nordrhein Westfalen, Germany
Universitaetsklinikum Duesseldorf AoeR
🇩🇪Duesseldorf, Nordrhein Westfalen, Germany
Klinikum Altenburger Land GmbH
🇩🇪Altenburg, Thueringen, Germany
Universitaetsklinikum Koeln
🇩🇪Koeln, Nordrhein Westfalen, Germany
Emovis GmbH
🇩🇪Berlin, Germany
Ospedale degli Infermi
🇮🇹Ponderano, Biella, Italy
Fondazione Istituto G.Giglio di Cefalù
🇮🇹Cefalù, Palermo, Italy
ASST di Monza
🇮🇹Monza, Milano, Italy
Fondazione IRCCS Istituto Neurologico Carlo Besta
🇮🇹Milano, Italy
Azienda Ospedaliero Universitaria San Martino
🇮🇹Genova, Italy
Ospedale San Raffaele
🇮🇹Milano, Italy
Azienda Ospedaliera e Universitaria di Perugia
🇮🇹Perugia, Italy
Azienda Ospedaliero Universitaria Pisana
🇮🇹Pisa, Italy
AOU dell'Università degli studi della Campania Luigi Vanvitelli
🇮🇹Napoli, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
🇮🇹Roma, Italy
Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza
🇮🇹Roma, Italy
Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'Aragona
🇮🇹Salerno, Italy
Fondazione Santa Lucia IRCCS
🇮🇹Roma, Italy
Seoul National University Bundang Hospital
🇰🇷Seongnam, Gyeonggi-do, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Amphia Ziekenhuis, Molengracht
🇳🇱Breda, Netherlands
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Podlaskie Centrum Psychogeriatrii
🇵🇱Bialystok, Poland
Klinika Psychiatrii Doroslych UCK
🇵🇱Gdansk, Poland
NZOZ "NEURO-KARD", "Ilkowski i Partnerzy" Sp. Partn. Lek.
🇵🇱Poznan, Poland
Neuro-Care Gabriela Klodowska
🇵🇱Siemianowice Slaskie, Poland
Centrum Medyczne NeuroProtect
🇵🇱Warszawa, Poland
NZOZ Wroclawskie Centrum Alzheimerowskie
🇵🇱Wroclaw, Poland
Hospital de Braga
🇵🇹Braga, Portugal
Centro Hospitalar e Universitário de Coimbra E.P.E - Hospitais da Universidade de Coimbra
🇵🇹Coimbra, Portugal
Hospital General Universitario de Elche
🇪🇸Elche, Alicante, Spain
CNS-Campus Neurologico Senior
🇵🇹Torres Vedras, Portugal
Clinica Universidad de Navarra
🇪🇸Pamplona, Navarra, Spain
CAE Oroitu
🇪🇸Getxo, Vizcaya, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Hospital Clinic de Barcelona
🇪🇸Barcelona, Spain
Hospital Universitari de Santa Maria
🇪🇸Lleida, Spain
Hospital Universitario Dr. Peset
🇪🇸Valencia, Spain
Hospital Victoria Eugenia
🇪🇸Sevilla, Spain
Skånes Universitetssjukhus
🇸🇪Malmö, Sweden
Sahlgrenska Universitetssjukhuset, Mölndal Sjukhus
🇸🇪Mölndal, Sweden
Akademiska Sjukhuset
🇸🇪Uppsala, Sweden
Hôpitaux Universitaires de Geneve- HUG
🇨🇭Genève, Switzerland
Ospedale Regionale di Lugano
🇨🇭Lugano, Switzerland
Centre Hospitalier Universitaire Vaudois
🇨🇭Lausanne, Switzerland
Changhua Christian Medical Foundation Changhua Christian Hospital
🇨🇳Changhua, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Chang Gung Memorial Hospital, Linkou
🇨🇳Taoyuan City, Taiwan
Re:Cognition Health Ltd (London)
🇬🇧London, Greater London, United Kingdom
The National Hospital for Neurology and Neurosurgery Centre
🇬🇧London, Greater London, United Kingdom
The University of Edinburgh
🇬🇧Edinburgh, Lothian Region, United Kingdom
Manchester Royal Infirmary
🇬🇧Manchester, Greater Manchester, United Kingdom
Queen Elizabeth University Hospital Campus
🇬🇧Glasgow, Strathclyde, United Kingdom
Glasgow Memory Clinic Ltd
🇬🇧Motherwell, Strathclyde, United Kingdom
The RICE Centre
🇬🇧Bath, Somerset, United Kingdom
Invicro
🇺🇸New Haven, Connecticut, United States
Yale University School Of Medicine
🇺🇸New Haven, Connecticut, United States
Accelerated Enrollment Solutions (AES)
🇺🇸Orlando, Florida, United States
Clinical Neuroscience Solutions, Inc.
🇺🇸Orlando, Florida, United States
Gastroenterology Associates of the Piedmont
🇺🇸Winston-Salem, North Carolina, United States
Wake Forest Baptist Health
🇺🇸Winston-Salem, North Carolina, United States
Roper St. Francis Healthcare
🇺🇸Charleston, South Carolina, United States
Medical University of South Carolina (MUSC)
🇺🇸Charleston, South Carolina, United States
National Clinical Research Inc.-Richmond
🇺🇸Richmond, Virginia, United States
Banner Alzheimer's Institute
🇺🇸Phoenix, Arizona, United States
Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie
🇵🇱Lublin, Poland
Georgetown University Clinical Research Unit (CRU)
🇺🇸Washington, District of Columbia, United States
Spitalzentrum Biel
🇨🇭Biel/Bienne, Switzerland
Dignity Health
🇺🇸Phoenix, Arizona, United States
Hospital Beatriz Ângelo
🇵🇹Loures, Portugal
Hospital Universitario Reina Sofia
🇪🇸Cordoba, Córdoba, Spain
Institut fur Regenerative Medizin-IREM Universitat Zurich, Campus Schlieren
🇨🇭Schlieren, Switzerland
Senior Adult Specialty Research
🇺🇸Austin, Texas, United States
Banner Sun Health Research Institute
🇺🇸Sun City, Arizona, United States
Rhode Island Hospital
🇺🇸Providence, Rhode Island, United States
Charing Cross Hospital
🇬🇧London, Greater London, United Kingdom