ACTRN12614001180606终止4 期
A pharmacokinetic study of renal clearance of metformin in patients with impaired renal function.
Dr Dan Wright0 个研究点目标入组 45 人开始时间: 2014年11月11日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 发起方
- 入组人数
- 45
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomised trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •1. Subjects with a measured eGFR either <=30mL/min, between >30 & <= 60mL/min and > 60 mL/min
- •2. Subjects who are >18 years of age.
排除标准
- •1.Subjects who are unable or unwilling to give written informed consent
- •2.Subjects with Type 2 diabetes or who are currently taking metformin
- •3.Subjects with evidence of >25% change in eGFR in the past month
- •4.Significant asthma, heart failure or any condition associated with a fragile fluid balance (potential reaction to beta-blockade)
- •5.Pregnancy
- •6.Known allergy to medication classes; biguanides or aminoglycosides.
- •7.The concomitant use of drugs known or suspected to interact with the tubular transport of metformin or creatinine including: antibiotics (unless a 2 week washout), beta-blockers, calcium channel blockers, antiarrhythmic drugs, H2 blockers, thiazide diuretics (unless a 7 day washout), antituberculosis drugs, and probenecid.
研究者
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