Soy protein intake and the metabolic syndrome, reducing inflammation to improve insulin resistance and glucose homeostasis - Soy protein intake and the metabolic syndrome

Wageningen Universiteit0 个研究点目标入组 15 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•Central obesity: waist circumference >=80 cm plus any one of the following four factors:
•- Raised triglyceride level: >=1.7 mmol/L;
•- Reduced high-density lipoprotein (HDL) cholesterol: <1.29 mmol/L
•- Raised blood pressure: systolic BP >=135 mmHg or diastolic BP >=85 mmHg or use of blood pressure lowering medication
•- Raised fasting plasma glucose >= 5.6 mmol/L
•Additional inclusion criteria:
•45-70 years
•No menstrual cycle for >=1 year
•Stable body weight for >=6 months (no weight gain/loss > 3 kg)
•Stable exercise habits during the last 6 months, and not participating in any vigorous exercise program

•*(Undiagnosed) Diabetes - but not impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) as evaluated by an oral glucose tolerance test at screening
•*Active hearth disease, i.e. history of myocardial infarction, stroke or angina pectoris
•*A history of stroke, coronary heart diseases, thyroid disease, or breast, uterine or ovarian cancer, or other malignancies in the past 5 years
•*Two sided ovariectomy
•*Drug use knowing to interfere with objectives of the study
•- oral corticosteroids, lipid-lowering drugs (such as statins)
•- anti-conceptive use (such as the pill or IUD)
•- hormone replacement therapy
•- long-term antibiotics use
•- isoflavone supplements
•*Allergic to soy or dairy products
•*Vegetarian
•*Following, or have recently followed a (weight-loss) diet
•*Habitual intake of soy foods (>1 soy food per week)
•*Donated or intended to donate blood 2 months before till two months after the study
•*more than 7 alcoholconsumptions per week
•*Participation in another biomedical study within 1 month before the first screening visit
•*Not willing to be informed if deviations are found in blood samples
•*Contraindications to MRI scanning

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