The Diagnostic Assessment and Intervention Study of Amphetamine Type Stimulus

Not Applicable

Completed

• Conditions: Amphetamine Addiction
• Interventions: Radiation: rTMS 10HZ high frequency stimulation; Behavioral: psychological rehabilitation training; Behavioral: physical and neurological rehabilitation training; Radiation: fake rTMS 10HZ high frequency stimulation

• Registration Number: NCT02285556
• Lead Sponsor: Shanghai Mental Health Center

Brief Summary

The purpose of this research is to inspire new medical ideas using brain image technology for the treatment of Amphetamine Type Stimulus addition, at the same time lowing the addition damage.

Detailed Description

The study will increase the sample size based on the preliminary work,also, establish drug dependence induced craving associated environmental experiments , by using the multi-lead biofeedback instrument , CogState tester, event-related potentials Recorder and 3.0T high-field magnetic resonance imaging system to record the physiology , electrophysiology and brain changes during craving, taking a subjective self-assessment , clinical observations and physiological responses combined system to evaluate the ATS addiction degree.

Study Timeline

• Study Start: 2012-03
• Study First Submitted: 2014-08-19
• Primary Completion: 2014-11
• Study Completion: 2014-11
• Study First Submitted QC: 2014-11-04
• Study First Posted: 2014-11-07
• Status Verified: 2015-11
• Last Update Submitted: 2015-11-16
• Last Update Posted: 2015-11-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 560

Inclusion Criteria

• No previous history of any mental disorder meet the DSM-IV diagnosis
• aged 18-49 years old , men and women
• junior high school or higher education
• use of amphetamine-type substances time for more than one year
• cumulative use of amphetamines, substances dose of 50 grams or more.

Exclusion Criteria

• Current or past had suffered neurological diseases
• exclusion of antisocial personality disorder and borderline personality disorder
• addicts in addition to other substances in tobacco , coffee, social drinking outside
• AIDS virus (HIV) detection positive patients .

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
brain stimulation intervention	rTMS 10HZ high frequency stimulation	Use randomized, prospective pseudo stimulus controlled clinical trial design, evaluation of repetitive transcranial magnetic stimulation of the left frontal lobe dorsal lateral effect on ATS dependent induced cognitive dysfunction and other symptoms.
psychological training intervention	psychological rehabilitation training	The main content is self-awareness training, social and moral strengthening, impulse control training , problem solving training , situational awareness training , HIV prevention, social skills training under the family atmosphere , family social skills training , interpersonal skills training, community interaction skills training , psychiatric symptoms of self-monitoring skills training and so on.
physical and neurological rehabilitation	physical and neurological rehabilitation training	The main content is drug rehabilitation exercise and functional physical training. Rehabilitation led by the discipline cadres , practice once a day, each lasting about 15 minutes .
fake brain stimulation intervention	fake rTMS 10HZ high frequency stimulation	fake transcranial magnetic stimulation of the left frontal lobe dorsal lateral effect on ATS dependent induced cognitive dysfunction and other symptoms.

Primary Outcome Measures

Name	Time	Method
the prevalence of ATS abuse or dependence characteristics and pathogenesis	Baseline	Plasma and DNA samples were collected to carry out the biochemical genetics and immunology research of ATS abuse or dependence , and to explore the prevalence of ATS abuse or dependence characteristics and pathogenesis.
the physiological psychology and cognitive impairment characteristic of ATS addicts,trends and ATS conducted cases.	Baseline	Use repeatable battery for the assessment of neuropsychological status(RBANS),Cog-state cognitive function assessment test,event-related potentials(ERPs),functional magnetic resonance imaging(fMRI) in biology ( molecular genetics, blood biochemistry, electrophysiology , imaging ) , psychology, mental health and other aspects of the system to assess the physiological psychology and cognitive impairment characteristic of ATS addicts , trends and ATS conducted cases.

Trial Locations

Locations (1)

Shanghai Mental Health Center; 🇨🇳 Shanghai, Shanghai, China