Diameter Changes of Retinal Vessels During Hypoxia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 58
- 试验地点
- 1
- 主要终点
- Diameter changes of retinal vessels
研究概览
简要总结
The primary objective is to study if an inhibition of nitric oxide and/or prostaglandins affect the diameter changes of retinal vessels observed during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diabetes type 1 without retinopathy
- •Diabetic retinopathy
排除标准
- •Cardio-vascular disease
- •Lung disease
- •Pregnancy
- •Previous ocular disease other than retinal branch vein occlusion
- •Previous treatment with medications influencing on the intraocular pressure or the metabolism of nitric oxide or prostaglandins
研究组 & 干预措施
Hypoxia
Inhaling hypoxic gas mixture to induce hypoxemia during recordings of diameter changes of retinal vessels. Recording are performed during hypoxia alone and in combination with the associated interventions at two examination days.
干预措施: COX inhibitor (Other)
Hypoxia
Inhaling hypoxic gas mixture to induce hypoxemia during recordings of diameter changes of retinal vessels. Recording are performed during hypoxia alone and in combination with the associated interventions at two examination days.
干预措施: L-NG-monomethyl arginine citrate (Other)
Hypoxia
Inhaling hypoxic gas mixture to induce hypoxemia during recordings of diameter changes of retinal vessels. Recording are performed during hypoxia alone and in combination with the associated interventions at two examination days.
干预措施: COX inhibitor + L-NG-monomethyl arginine citrate (Other)
Normoxia
Breathing atmospheric air during recordings of diameter changes of retinal vessels. Recording are performed during normoxia alone and in combination with the associated interventions at two examination days.
干预措施: COX inhibitor (Other)
Normoxia
Breathing atmospheric air during recordings of diameter changes of retinal vessels. Recording are performed during normoxia alone and in combination with the associated interventions at two examination days.
干预措施: L-NG-monomethyl arginine citrate (Other)
Normoxia
Breathing atmospheric air during recordings of diameter changes of retinal vessels. Recording are performed during normoxia alone and in combination with the associated interventions at two examination days.
干预措施: COX inhibitor + L-NG-monomethyl arginine citrate (Other)
结局指标
主要结局
Diameter changes of retinal vessels
时间窗: Examination day 1 and 2
Comparing the differences of diameter changes occuring during each of the interventions.
次要结局
未报告次要终点