Heart rate variability as a Parameter of intraoperative homeostasis of the autonomic nervous system
- Conditions
- Depth of Anaesthesia
- Registration Number
- DRKS00024696
- Lead Sponsor
- niversitätsklinikum Mannheim
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 50
Inclusion Criteria
Male, undergo a Prostektomy with general Anaesthesia, between 20 and 80 jears of age
Exclusion Criteria
Exclusion criteria included age less than 18 and greater than 85 years, diabetes mellitus, ASA status > 2, use of medications affecting the autonomic nervous system, e.g., ß-blockers, antiarrhythmics, and atropine, implantation of a pacemaker, and cardiac arrhythmia.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome of the study is to investigate the level of agreement between the HRV parameters (SDNN, RMSSD, HF, LF, LF/HF ratio), the Narcotrend Index of the EEG-based Narcotrend Monitor for the detection of the depth of anesthesia, and the MAC of the inhalation anesthetic sevoflurane across the entire course of surgery.
- Secondary Outcome Measures
Name Time Method The secondary outcome of the study is, that HRV parameters correlate with the Narcotrend Index and reflect central sedation in addition to ANS activity during general anesthesia.