Evolution of Pulmonary Capillary Blood Volume

Completed

• Conditions: Pulmonary Embolism
• Interventions: Other: diffusion NO/CO method

• Registration Number: NCT00941187
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

The purpose of this monocentric, preliminary study is to assess the evolution of pulmonary capillary blood volume (Vc), measured by the double diffusion nitric oxide/carbon monoxide (NO/CO) method (Guenard et al.; Respir Physiol 1987), from the starting of the anticoagulant therapy to 6 months after, and to search correlations with the evolution of clinical (dyspnea and results of the 6 minutes walking test), biological (BNP; Troponin), echocardiographic (right ventricular dysfunction, pulmonary arterial pressure) and ventilation/perfusion lung scan data.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2009-07-16
• Study First Submitted QC: 2009-07-16
• Study First Posted: 2009-07-17
• Study Start: 2009-08
• Primary Completion: 2012-12
• Study Completion: 2012-12
• Status Verified: 2013-11
• Last Update Submitted: 2013-11-06
• Last Update Posted: 2013-11-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patient with a first episode of symptomatic pulmonary embolism, treated with anticoagulant
• Age from 18 to 75 years-old

Exclusion Criteria

• Confirmed pulmonary embolism in the past
• Massive pulmonary embolism, thrombolytic treatment
• Confirmed left heart systolic dysfunction
• Confirmed asthma, chronic obstructive pulmonary disease or pulmonary fibrosis
• Expected life below 6 months
• Pleural effusion with indication of evacuation
• Bronchopulmonary cancer
• Pulmonary surgery with resection of two lobes minimum
• Predictable incapacity to complete the 6 minutes walking test

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
patients after a first episode of pulmonary embolism	diffusion NO/CO method	-

Primary Outcome Measures

Name	Time	Method
difference of pulmonary capillary blood volume (Vc) from J0 to 6 months	from the starting of the anticoagulant therapy to 6 months after

Secondary Outcome Measures

Name	Time	Method
correlations with the evolution of clinical (dyspnea and results of the 6 minutes walking test), biological (BNP; Troponin), echocardiographic (right ventricular dysfunction, pulmonary arterial pressure) and ventilation/perfusion lung scan data	from the starting of the anticoagulant therapy to 6 months after

Trial Locations

Locations (2)

Departement of pneumology, CHU Saint-Etienne; 🇫🇷 Saint-Etienne, France

Department of Medicine and Therapeutic, CHU Saint-Etienne; 🇫🇷 Saint-etienne, France