NCT00941187已完成不适用
Evolution of Pulmonary Capillary Blood Volume (Vc) in Patients After a First Episode of Pulmonary Embolism.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- difference of pulmonary capillary blood volume (Vc) from J0 to 6 months
研究概览
简要总结
The purpose of this monocentric, preliminary study is to assess the evolution of pulmonary capillary blood volume (Vc), measured by the double diffusion nitric oxide/carbon monoxide (NO/CO) method (Guenard et al.; Respir Physiol 1987), from the starting of the anticoagulant therapy to 6 months after, and to search correlations with the evolution of clinical (dyspnea and results of the 6 minutes walking test), biological (BNP; Troponin), echocardiographic (right ventricular dysfunction, pulmonary arterial pressure) and ventilation/perfusion lung scan data.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient with a first episode of symptomatic pulmonary embolism, treated with anticoagulant
- •Age from 18 to 75 years-old
排除标准
- •Confirmed pulmonary embolism in the past
- •Massive pulmonary embolism, thrombolytic treatment
- •Confirmed left heart systolic dysfunction
- •Confirmed asthma, chronic obstructive pulmonary disease or pulmonary fibrosis
- •Expected life below 6 months
- •Pleural effusion with indication of evacuation
- •Bronchopulmonary cancer
- •Pulmonary surgery with resection of two lobes minimum
- •Predictable incapacity to complete the 6 minutes walking test
结局指标
主要结局
difference of pulmonary capillary blood volume (Vc) from J0 to 6 months
时间窗: from the starting of the anticoagulant therapy to 6 months after
次要结局
- correlations with the evolution of clinical (dyspnea and results of the 6 minutes walking test), biological (BNP; Troponin), echocardiographic (right ventricular dysfunction, pulmonary arterial pressure) and ventilation/perfusion lung scan data(from the starting of the anticoagulant therapy to 6 months after)
研究者
研究点 (2)
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