Calculation Of Lung Inflation in Neonates

Not Applicable

Completed

• Conditions: neonate; Respiratory Diseases; Mechanical Ventilation; Computerised Tomography; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12623000903684
• Lead Sponsor: Murdoch Childrens Research institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-08-23
• Study Completion: 2024-01-30
• Last Update Posted: 4 March 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 218

Inclusion Criteria

Neonates will be eligible if they have had a CT chest within the first 31 days of life (corrected gestational age) at the Royal Children’s Hospital in Melbourne, Victoria.

Exclusion Criteria

Neonates will be excluded if they meet the following criteria:
1. The CT scan is conducted after 31 days corrected gestational age.
2. The scout CXR has a cardiothoracic ratio above 0.6 indicating cardiomegaly and distortion of the thoracic structures.
3. The scout CXR shows significant lordosis or scoliosis which would distort accurate assessment of rib/diaphragm relationship.
4. A single ventricle is identified on the CT scan.
5. Participants suffer from congenital lung pathology including congenital diaphragmatic hernia, congenital pulmonary airway malformation (previously congenital cystic adenomatoid malformations), pulmonary sequestration, congenital lobar emphysema, bronchogenic cysts.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The distribution of total lung volume (ml/kg body weight) at each of the measured diaphragm positions in the study cohort (6-11 ribs). [ Time Computerised Tomography scan was performed]