The diagnostic significance of quantitative chest CT emphysema index and emphysema distribution type for asthma-copd overlap (ACO)

Not Applicable

Recruiting

• Conditions: Asthma-COPD Overlap, ACO

• Registration Number: ITMCTR2000003889
• Lead Sponsor: Gansu Provincial Hospital of TCM

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Asthma group: Patients with stable asthma according to gina2017 diagnostic criteria were included;
1. The symptoms such as wheezing, shortness of breath, chest tightness, cough and other symptoms recur clearly, which are related to exposure to cold air, physical and chemical stimulation, upper respiratory tract infection and exercise. The intensity changes with time, and can be relieved by antiasthmatic drugs or by itself.
2. Definite reversibility of airflow restriction: positive bronchodilation test (fevl. 0 improved more than 200 ml and more than 12%) after inhalation of bronchodilator drugs;
3. Asthma patients with fixed airflow limitation were also included in the asthma group (FEV1.0 / FVC < 0.7).
COPD group: stable COPD patients meeting gold 2013 diagnostic criteria were included.
1. FEV1.0 / FVC < 0.7 after bronchodilation test;
2. Smoking history is more than 10 pack years or have a clear history of harmful smoke exposure;
3. Chronic cough, expectoration, asthma and other respiratory symptoms;
4. Patients with previous asthma or recurrent wheezing were excluded.
Normal control group: healthy non-smokers were included.
1. No smoking history;
2. No history of chronic or severe respiratory diseases, no respiratory symptoms;
3. The pulmonary ventilation function was normal (FEV1.0 / FVC > 0.7 and greater than 92% of the predicted value; FEV1.0 and FVC were greater than 80% of the predicted value, and the shape of flow volume curve was normal;
4. Chest CT examination showed no structural lesions, no pulmonary nodules or masses larger than LCM.

Exclusion Criteria

1. Patients with acute exacerbation within 6 weeks;
2. Chest CT showed that the diameter of lung mass was larger than 3cm;
3. Patients with other severe respiratory diseases, such as extensive bronchiectasis, interstitial lung disease, lung cancer, infectious lung disease, massive pleural effusion, etc;
4. Patients with history of chest trauma or surgery;
5. Patients with other serious diseases: heart failure, severe liver and kidney dysfunction, severe anemia, mental disorders, etc.
6. Patients who cannot cooperate with history collection, pulmonary function or chest CT examination.

Study & Design

• Study Type: Observational study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
(Emphysema Index(EI);

Secondary Outcome Measures

Name	Time	Method
Pulmonary function test;