Effects of Mixed Nut Consumption on Satiety and Weight Management

Not Applicable

Recruiting

• Conditions: Satiety
• Interventions: Other: Pretzels; Other: Mixed nuts

• Registration Number: NCT03375866
• Lead Sponsor: San Diego State University

Brief Summary

The first goal of the proposed study is to determine acute and long-term effects of mixed nuts (almonds, hazelnuts, pecans, pistachios, walnuts, and peanuts) on metabolic parameters and weight management. While numerous studies have shown the beneficial effects of nuts on promoting negative energy balance and weight loss, mechanistic studies exploring how the inclusion of nuts in the diet promotes a negative energy balance and weight loss have not been conducted. The second goal is to determine the mechanisms by which mixed nut consumption regulates of food intake and body weight.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-12
• Study First Submitted: 2017-12-11
• Study First Submitted QC: 2017-12-14
• Study First Posted: 2017-12-18
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-26
• Last Update Posted: 2025-04-01
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

• 18-55 years old
• BMI 27-40

Exclusion Criteria

• Smoker
• Pregnant woman
• Required dietary supplement use
• Required medication of metabolic disorders
• Allergy to nuts or gluten

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Pretzels	Pretzels	-
Mixed nuts	Mixed nuts	-

Primary Outcome Measures

Name	Time	Method
Change of Satiety	0, 20, 40, 60, 90 and 120 minutes post snack consumption	Hunger feeling (appetite) will be examined using visual analog scale (0-10): 0 least and 10 greatest
Change of insulin level	Baseline, 40 minutes post snack consumption, and 8 weeks and 16 weeks post daily consumption	Insulin level will be examined using an ELISA biochemical method
Change of glucose level	Baseline, 40 minutes post snack consumption, and 8 weeks and 16 weeks post daily consumption	Glucose level will be examined using glucose analysis
Change of cholesterol levels	8 weeks and 16 weeks post daily consumption	Cholesterol levels will be examined using a biochemical method
Change of Lp(a)	8 weeks and 16 weeks post daily consumption	Lp(a) levels will be examined using an ELISA biochemical method

Secondary Outcome Measures

Name	Time	Method
Change of microbiome	8 weeks and 16 weeks post daily consumption	Diversity of microbiome will be analyzed in fecal samples

Trial Locations

Locations (1)

School of Exercise and Nutritional Sciences, SDSU; 🇺🇸 San Diego, California, United States