Studies of the Pathogenesis and Natural History of Arthritis and Related Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 697
- Locations
- 1
- Primary Endpoint
- Determine patterns of arthritis
Study Overview
Brief Summary
This research protocol will recruit patients with arthritis and related conditions for the purpose of screening patients for treatment protocols, and evaluating the natural history of arthritis and related conditions. Patients will be evaluated clinically, radiographically and serologically, and standardized data will be uniformly collected on all patients. Additional imaging using sensitive MRI methods will be obtained in some patients. The collected blood and tissue will be utilized for laboratory studies to continue research on the pathogenic mechanisms of rheumatoid arthritis and related autoimmune joint diseases. Data from the history and physical examination as well as several disability questionnaires in the adult and pediatric population will be used to phenotypically characterize these patients and assess outcome and functional status. Any medical care recommended or provided to the patients will be consistent with routine standards of practice and provided in consultation with the patient's referring physician.
Detailed Description
This research protocol will recruit patients with arthritis and related conditions for the purpose of screening patients for treatment protocols, and evaluating the natural history of arthritis and related conditions. Patients will be evaluated clinically, radiographically and serologically, and standardized data will be uniformly collected on all patients. Additional imaging using sensitive MRI methods will be obtained in some patients. The collected blood and tissue will be utilized for laboratory studies to continue research on the pathogenic mechanisms of rheumatoid arthritis and related autoimmune joint diseases. Data from the history and physical examination as well as several disability questionnaires in the adult and pediatric population will be used to phenotypically characterize these patients and assess outcome and functional status. Any medical care recommended or provided to the patients will be consistent with routine standards of practice and provided in consultation with the patient's referring physician.
Study Design
- Study Type
- Observational
- Observational Model
- Case Only
- Time Perspective
- Prospective
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Determine patterns of arthritis
Time Frame: End of the study
Evaluate natural history and disease trajectories in rheumatoid arthritis
Secondary Outcomes
- Assess cytokine profiles(End of the study)
- Correlate the cartilage and bone markers of tissue destruction and repair with MRI images(End of the study)
- Determine the degree of early disability(End of the study)
- MRI Imaging in RA and related diseases(End of the study)
- Evaluation of early disability in RA and related diseases(End of the study)
- Co-culture experiments using synovial tissue and surgical cartilage specimens(End of the study)
- Confirmatory Studies In RA and related diseases(End of the study)
- Collection of DNA in RA and related diseases(End of the study)