The role of bile acids in human brown adipose tissue metabolism

Completed

• Conditions: bile acids; brown adipose tissue; 10003018

• Registration Number: NL-OMON38439
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 18

Inclusion Criteria

- Caucasians
- Age: 18-30 years
- Gender: male and female (females only on a specific oral contraceptive pill; microgynon 30 or levonorgestrel/ethinylestradiol)
- BMI: 18-25 kg/m2
- Good general health

Exclusion Criteria

- Psychologically unstable subjects (as judged by the treating medical specialist)
- Subjects with mental retardation (as judged by the treating medical specialist)
- Subjects with severe behavior disorders (as judged by the treating medical specialist)
- Pregnancy or lactation
- The use of the following medication one month before the study is an exclusion criterium; ß-blockers, ursodeoxycholic acid, bile acid sequestrants and antacida
- Participation in an intensive weight-loss program or vigorous exercise program during the last year before the start of the study
- Abuse of drugs and/or alcohol
- Severe diabetes which requires application of insulin or patients with diabetes-related complications
- Surgery of the gastro-intestinal tract (only appendectomy is allowed)
- Previous ERCP with papillotomy
- History of cholesystectomy or disease of the gallbladder, biliary system and/or liver
- Hyperthyroidism or hypothyroidism
- BMI > 25 kg/m2
- Participation in earlier research or medical examinations that included PET/CT scanning

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are BAT activity, which will be measured by means of<br /><br>PET-CT scanning, and (non-shivering) thermogenesis, which will be measured by<br /><br>means of indirect calorimetry. In addition, skeletal muscle mitochondrial<br /><br>uncoupling capacity will be determined as well. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Body temperature distribution, body composition and skin perfusion.</p><br>