ocal Endometrial Trauma (LET) in Patients with Recurrent Implantation Failure

Withdrawn

• Conditions: Recurrent implantation failure; Reproductive Health and Childbirth - Fertility including in vitro fertilisation

• Registration Number: ACTRN12613001046796
• Lead Sponsor: Prof William Ledger

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-09-19
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Female
• Target Recruitment: 148

Inclusion Criteria

Patients about to undergo a cycle of IVF/ICSI treatment involving fresh embryo transfer, who has a history of recurrent implantation failure in IVF/ICSI treatment.

Exclusion Criteria

Patient under 21 or over 39 years of age
Known uterine abnormality
Medical contradiction to superovulation, oocyte collection or embryo transfer
Unable to give informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical pregnancy (i.e. the prescence of fetal heart activity as seen on transvaginal ultrasound approxiamtely four weeks after embryo transfer).[4 weeks after embryo transfer]

Secondary Outcome Measures

Name	Time	Method
The effect of the LET procedure on positive serum HCG pregnancy test two weeks after embryo transfer[2 weeks after embryo transfer];Pregnancy outcome up to delivery. Seen by regular pregnancy monitoring such as ultrasound, blood pressure testing and urine testing.[40 weeks];Endometrial tissue collected during the LET will be analysed for markers of successful implantation such as activin A, activin B, follistatin and their receptors.[Mid luteal phase in the month immediately preceding the IVF treatment]