Effects of natural and commercial orange juice consumption in inflammatory factors ( hs-CRP; ICAM; VCAM; IL-6; E-Selectin )and endothelial function evaluation (FMD ) in healthy volunteers

Not Applicable

• Conditions: Condition 1: Blood pressure. Condition 2: flow-mediated dilatation (FMD).; Diseases of arteries, arterioles and capillaries; Hypertensive diseases; I10-I15; I70-I79

• Registration Number: IRCT201205079662N2
• Lead Sponsor: Isfahan University of Medical Sciences

Brief Summary

Abstract <br /> BACKGROUND: Citrus sinensis juice (CSJ) is a rich source of dietary flavonoids which reduce <br /> the risk of adverse cardiovascular events. This study aimed to examine the effects of four-week <br /> intake of natural and commercial orange (Citrus sinensis) juice on blood pressure in healthy <br /> volunteers. <br /> METHODS: In this single-blind randomized crossover study, 22 healthy subjects (age: 18-59 <br /> years old) were included and randomly divided into two groups of 11. Group A consumed <br /> commercial CSJ during the first four-week period. After a two-week washout period, they <br /> consumed natural CSJ for another four weeks. The procedure was reversed in group B. The <br /> participants were asked to drink 500 ml/day of either natural or commercial CSJ twice a day <br /> with breakfast and dinner. The effects of orange juice on blood pressure were evaluated. <br /> RESULTS: After drinking commercial CSJ, diastolic and systolic blood pressure were <br /> significantly decreased (5.13%; P = 0.03 and -5.91%; P = 0.003, respectively). However, <br /> consumption of natural CSJ did not have significant effects on either diastolic or systolic blood <br /> pressure. <br /> CONCLUSION: Commercial CSJ significantly decreased blood pressure. Higher flavonoid, <br /> pectin, and essential oils content of concentrated products compared to natural juice might have <br /> been responsible for this finding. Nevertheless, further studies to focus on dose-response effects <br /> are recommended. <br /> Keywords:Citrus sinensis Juice, Hypertension, Blood Pressure

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Healthy individuals 19-59 years.
Exclusion criteria: Individuals with a history of diseases; diabetes; cardiovascular disease; liver and kidney as well as those with thyroid disease; pregnant and breastfeeding; individuals with dyslipidemia, metabolic and endocrine diseases and those with a vegetarian diet.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Positive changes in inflammatory markers. Timepoint: Baseline and after 4 weeks. Method of measurement: ELISA kit.;Positive changes in endothelial function. Timepoint: Baseline and after 4 weeks. Method of measurement: Doppler ultrasonography.

Secondary Outcome Measures

Name	Time	Method
Decrease in blood pressure. Timepoint: Baseline and after 4 weeks. Method of measurement: Sphygmomanometer.;Positive changes in lipid profiles. Timepoint: Baseline and after 4 weeks. Method of measurement: kit.;Cholesterol Level. Timepoint: Before and after 4 weeks. Method of measurement: KIT.;HDL Level. Timepoint: Before and after 4 weeks. Method of measurement: KIT.;LDL level. Timepoint: Before and after 4 weeks. Method of measurement: KIT.