Effect of the Transcranial Direct Current Stimulation (tDCS) on Dependent Smoking People
- Conditions
- Tobacco Abuse Smoke
- Registration Number
- NCT02867514
- Lead Sponsor
- Centre Hospitalier Universitaire de Besancon
- Brief Summary
The purpose of this study is to evaluate the effect of 10 sessions of anodal transcranial Direct Current Stimulation (tDCS - 1 mA) applied to left vs right CDLPF of tobacco-dependent subjects compared to the application of a placebo tDCS (sham procedure) on the craving, which is evaluated by the item 1 of Fagerström test between day 1 and day 10. Craving is also evaluated 1 month post-treatment.
- Detailed Description
Tobacco is the second leading cause of death worldwide. It is currently responsible for the death of one in 10 adults (about 5 million deaths per year) and it is the fourth disease risk factor in the world. Many methods to quit smoking are available but in all cases, relapse is a common phenomena. The main risk factor for relapse is craving. So, acting on the craving seems essential to modulate tobacco consumption. Many functional neuroimaging studies have established a neuroanatomical substrate for craving process, in particularly dorsolateral prefrontal cortex (DLPFC), accessible par neuromodulation.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
- Fagerström score ≥ 5
- Q-MAT score ≥ 6
- smoking subjects from 10 to 30 cigarettes a day
- right-handed subjects
- w/o severe progressive somatic pathology (especially tumor diseases, degenerative diseases)
- Hamilton Depression Rating Scale-17 score <18
- pregnancy and/or lactation
- presence of a specific contraindication for tDCS (e.g. personal history of epilepsy, metallic head implant, cardiac pacemaker...)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method change from baseline in craving evaluated by item 1 of Fagerström test baseline, day 10 and 1 month post-ttt before and after the 10 sessions
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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Trial Locations
- Locations (2)
CHRU Besancon - Service de Psychiatrie - Centre Investigation Clinique Innovation Technologique (CIC-IT808)
🇫🇷Besancon, France
Assistance Publique - Hôpitaux de Paris
🇫🇷Paris, France
CHRU Besancon - Service de Psychiatrie - Centre Investigation Clinique Innovation Technologique (CIC-IT808)🇫🇷Besancon, FranceEmmanuel HAFFEN, MD PhDPrincipal InvestigatorMagali NICOLIER, PhDContact+33381219007mnicolier@chu-besancon.fr