Effects of Oxytocin and Vasopressin on Moral Decision Making

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Drug: Placebo; Drug: Vasopressin; Drug: Oxytocin

• Registration Number: NCT04890470
• Lead Sponsor: University of Electronic Science and Technology of China

Brief Summary

To determine whether the neuropeptide oxytocin (OXT) and vassopressin (AVP) influence moral decision making

Detailed Description

In a double-blind, between- subject placebo (PLC) controlled design, subjects will first complete a series of questionnaires in terms of mood, clinical symptoms, and traits. After that their moral judgment and emotion towards both verbal descriptions of moral dilemma scenarios and pictures of specific interpersonal ones will be assessed and the effect of intranasal OXT and AVP between both male and female healthy subjects will be investigated.

Study Timeline

• Study Start: 2021-03-02
• Study First Submitted: 2021-05-12
• Study First Submitted QC: 2021-05-16
• Study First Posted: 2021-05-18
• Primary Completion: 2022-12-12
• Study Completion: 2022-12-12
• Status Verified: 2023-09
• Last Update Submitted: 2023-09-19
• Last Update Posted: 2023-09-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

• healthy subjects without past or current psychiatric or neurological disorders

Exclusion Criteria

• pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
placebo group	Placebo	subjects with placebo treatment
vasopressin group	Vasopressin	subjects with vasopressin treatment
oxytocin group	Oxytocin	subjects with oxytocin treatment

Primary Outcome Measures

Name	Time	Method
Effect of OXT and AVP on behavioral index of moral decision task	45 mins - 105 mins	intensity of feelings

Trial Locations

Locations (1)

Xiaoxiao Zheng; 🇨🇳 Sichuan, Sichuan, China