The Effect of Remote Postconditioning on Graft Function in Patients Undergoing Living-related Kidney Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- renal function of recipient after living-related kidney transplantation
研究概览
简要总结
The purpose of this study is to investigate whether upper limb ischemic postconditioning can improve renal function and decrease ischemic-reperfusion injury in patients undergoing living donor kidney transplantation.
详细描述
Ischemic reperfusion injury after kidney transplantation is a common clinical problem associated with a high morbidity and mortality. To reduce the adverse effect of ischemic reperfusion injury after organ transplantation, various strategies including ischemic preconditioning or postconditioning. Remote ischemic postconditioning is one of such strategies where brief ischemic reperfusion injury of one organ protects other organs from sustained ischemic reperfusion injury. Remote ischemic postconditioning of the limb with a tourniquet is a safe and convenient method of postconditioning organs against ischemic reperfusion injury. However, the efficacy of remote ischemic postconditioning in patients undergoing living donor kidney transplantation needs to be established. Therefore, we investigate the efficacy of remote ischemic postconditioning of the upper limb with a tourniquet in recipients of kidney transplantation by measuring the markers of acute kidney injury.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects undergoing elective living donor kidney transplantation
- •subjects older than 20 yrs who can give written informed consent
排除标准
- •re-transplant recipients
- •those with peripheral vascular disease affecting the upper limbs free of arteriovenous fistula
结局指标
主要结局
renal function of recipient after living-related kidney transplantation
时间窗: at 72 h after declaming of renal artery
serum creatinine concentration and urine output
次要结局
- Biomarkers of acute kidney injury(before surgery and at 2, 6, 12 h after declaming of renal artery)
- Hemodynamic parameters(before surgery and at 2, 6, 12, 24, 48, 72 h after declaming of renal artery)
- outcome of kidney transplantation(at 72 h after declaming of renal artery)
- postoperative hospital stay(at postoperative day 60)
研究者
Jong Hwan Lee
Assistant Professor
Samsung Medical Center