Dietary Fiber and Gum Health: A Trial in Healthy Volunteers

Not Applicable

• Conditions: Gum disease; Inflammatory and Immune System - Other inflammatory or immune system disorders; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12623001067662
• Lead Sponsor: Professor Axel Spar

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-10-05
• Last Update Posted: 9 October 2023

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

We will recruit non-smoking, healthy (no cardiometabolic disease or gastrointestinal conditions or diabetes) participants (18-35 years old) with a minimum of 20 teeth and no clinical gingivitis (redness, swelling, bleeding), no probing pocket depth greater than or equal 3 mm at any site, no approximal attachment loss greater than or equal 2mm at any site and gingival index (GI)=0 at baseline from a pool of University staff and students registered as potential study participants.

Exclusion Criteria

Participants with less than 20 teeth and have clinical gingivitis (redness, swelling, bleeding), probing pocket depth greater than or equal 3mm at any site, approximal attachment loss greater than or equal 2mm at any site, and gingival index (GI)= or >1 will be excluded.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Activated MMP-8 in the gingival crevicular fluid will be assessed using QuickZyme Human MMP-8 Activity Assay Kit 96-Assays.[ MMP-8 will be assessed at baseline (just before starting supplementation), month one, month two, month three (immediately before pausing tooth brushing) and at the experiment end (immediately after 21 days of pausing tooth brushing). ]