Evaluating the effect of chewing sugar-free gums after recieving I-131, on absorbed dose in the salivary glands.

Phase 2

Conditions: Thyroid cancer therapy with I-131.
Malignant neoplasms of thyroid and other endocrine glands
C73-C75

Registration Number: IRCT2014062117684N5

Lead Sponsor: Shiraz university of medical science, Vice chancellor for research

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 60

Inclusion Criteria

Inclusion Criteria:
1-Patients older than 20 years for whom thyroidectomy has been performed for 4-6 weeks prior to initiation of the study due to differenciated thyroid cancer and are referred to Namazi Hospital Center of Nuclear Medicine for ablative radioactive iodine -131 therapy; 2-Patients who have received low-iodine diet for two weeks;
3-Patients must be at hypothyroid state at the time of the study;
4-Patients should have signed the informed consent form and should give permission for their participation in the study;

Exclusion Criteria

1-Any positive history of previous salivary gland diseases;
2-Any positive history of collagen tissue diseases;
3-Positive history of Phenylketonuria;
4-Positive history of using diuretics, Antihistamines, Antidepressants or Anticholinergic medications;
5-Positive history of previously receiving Radiotherapy at Head & Neck region;
6-Positive history of previous treatment with radioiodine ( 131I );
7-Difficulty in taking large amount of fluid;

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Radioiodine absorbed dose. Timepoint: 5 time points : At 2, 5, 13, 24 & 48 hours after receiving Radioiodine. Method of measurement: Radioiodine absorbed dose will be measured by scintigraphy and the amounts measured will be interpreted by MIRD Schema software.

Secondary Outcome Measures

Name	Time	Method
Incidence rate of Sialadenitis and Xerostomia in under study patients. Timepoint: Attime points: 1 week after initial admission period then monthly follow ups till 6 months. Method of measurement: By making phone calls at chosen time points and collecting subjective data about patients’ symptoms.