A 52-week, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg) Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI (Tanimilast) as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis. (PILLAR)
- Conditions
- Chronic Obstructive Pulmonary Disease
- Interventions
- Registration Number
- NCT04636814
- Lead Sponsor
- Chiesi Farmaceutici S.p.A.
- Brief Summary
The purpose of this study is to evaluate the efficacy and the safety of two doses of CHF6001 (Tanimilast) as add-on to maintenance triple therapy in the target patient population.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 3980
- Adults aged ≥ 40 years, with COPD and with chronic bronchitis.
- Current smokers or ex-smokers (history of ≥10 pack years).
- Post-bronchodilator FEV1 <50% of the patient predicted normal value and FEV1/FVC ratio < 0.7.
- At least, one moderate or severe COPD exacerbation in the previous year.
- CAT score ≥10.
- Subjects on regular maintenance triple therapy for at least 12 months prior to screening and receiving regular maintenance triple therapy for at least 3 months prior to screening visit.
- Subjects with current asthma.
- Subjects with moderate or severe COPD exacerbation 4 weeks before study entry and randomisation
- Subjects with known α-1 antitrypsin deficiency as the underlying cause of COPD.
- Subjects with primary diagnosis of emphysema not related to COPD.
- Subjects with known respiratory disorders other than COPD.
- Subjects with lung volume reduction surgery.
- Subjects with active cancer or a history of lung cancer.
- Subjects under Roflumilast treatment within 6 months before study entry.
- Subjects with a diagnosis of depression, generalised anxiety disorder, suicidal ideation.
- Subjects with clinically significant cardiovascular condition.
- Subjects with neurological disease.
- Subjects with clinically significant laboratory abnormalities.
- Subjects with moderate or severe hepatic impairment.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description CHF6001 3200µg CHF6001 3200µg - Placebo Placebo - Roflumilast Roflumilast - CHF6001 1600µg CHF6001 1600µg -
- Primary Outcome Measures
Name Time Method The number of moderate and severe exacerbations occurring during the planned 52-week treatment period. Up to 52 weeks Moderate or severe exacerbation is defined by symptomatic worsening of COPD:
* Moderate : requiring use of systemic corticosteroids (oral/IV/IM corticosteroids), and/or use of antibiotics
* Severe : requiring hospitalisation or resulting in death
- Secondary Outcome Measures
Name Time Method Change from baseline to last inter-visit period (week 40-52) in EXACT-Respiratory Symptoms (E-RS) Total and subscale scores. Up to 52 weeks Change from baseline to last inter-visit period (week 40-52) in EXACT-Respiratory Symptoms (E-RS) Total and subscale scores.
E-RS response (change from baseline E-RS Total score ≤ -2) at week 52. At week 52 E-RS response (change from baseline E-RS Total score ≤ -2) at week 52.
Time to moderate or severe exacerbation or study medication discontinuation due to any adverse event, lack of efficacy or death (composite endpoint) and time to study medication discontinuation component. Up to 52 weeks Time to moderate or severe exacerbation or study medication discontinuation due to any adverse event, lack of efficacy or death (composite endpoint) and time to study medication discontinuation component.
Key Secondary Variable: Change from baseline in SGRQ Total score at week 52 At week 52 Key Secondary Variable: Change from baseline in SGRQ Total score at week 52
Saint Georges Respiratory Questionnaire response (SGRQ) (change from baseline SGRQ total score ≤ -4) at week 52. At week 52 Saint Georges Respiratory Questionnaire response (SGRQ) (change from baseline SGRQ total score ≤ -4) at week 52.
Change from baseline to last inter-visit period (week 40-52) in the percentage of days without intake of rescue medication and in the average rescue medication use (number of puffs). Up to 52 weeks Change from baseline to last inter-visit period (week 40-52) in the percentage of days
Time to study medication discontinuation for any reason. Up to 52 weeks Time to study medication discontinuation for any reason.
Time to first moderate/severe exacerbation or study medication discontinuation due to any class-related AE, lack of efficacy, or death (composite endpoint) and time to study medication discontinuation component. Up to 52 weeks Time to first moderate/severe exacerbation or study medication discontinuation due to any class-related AE, lack of efficacy, or death (composite endpoint) and time to study medication discontinuation component.
The number of all on-treatment exacerbations requiring systemic corticosteroids. Up to 52 weeks The number of all on-treatment exacerbations requiring systemic corticosteroids.
The time to first moderate or severe exacerbation. Up to 52 weeks The time to first moderate or severe exacerbation.
The annual rate of severe exacerbations. Up to 52 weeks The annual rate of severe exacerbations.
The time to first severe exacerbation. Up to 52 weeks The time to first severe exacerbation.
The number of all on-treatment severe exacerbations. Up to 52 weeks The number of all on-treatment severe exacerbations.
Change from baseline (pre-dose Visit 2) in pre-dose FEV1, at week 52. At week 52 Change from baseline (pre-dose Visit 2) in pre-dose FEV1, at week 52.
Change from baseline in Saint Georges Respiratory Questionnaire (SGRQ) total and domain scores at week 52. At week 52 Change from baseline in Saint Georges Respiratory Questionnaire (SGRQ) total and domain scores at week 52.
Trial Locations
- Locations (461)
Chiesi Clinical Trial - Site 40503
🇦🇹Linz, Austria
Chiesi Clinical Trial - Site 40505
🇦🇹Wels, Austria
Chiesi Clinical Trial - Site 70553
🇧🇦Banja Luka, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 70555
🇧🇦Bihać, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 70554
🇧🇦Bijeljina, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 70557
🇧🇦Foča, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 70556
🇧🇦Gradiška, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 70560
🇧🇦Mostar, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 70562
🇧🇦Mostar, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 70559
🇧🇦Sarajevo, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 70561
🇧🇦Sarajevo, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 70551
🇧🇦Travnik, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 152507
🇨🇱Quillota, Chile
Chiesi Clinical Trial - Site 152503
🇨🇱Santiago, Chile
Chiesi Clinical Trial - Site 152504
🇨🇱Santiago, Chile
Chiesi Clinical Trial - Site 152508
🇨🇱Santiago, Chile
Chiesi Clinical Trial - Site 152509
🇨🇱Talca, Chile
Chiesi Clinical Trial - Site 152501
🇨🇱Valparaiso, Chile
Chiesi Clinical Trial - Site 191562
🇭🇷Dubrovnik, Croatia
Chiesi Clinical Trial - Site 191552
🇭🇷Karlovac, Croatia
Chiesi Clinical Trial - Site 191557
🇭🇷Osijek, Croatia
Chiesi Clinical Trial - Site 191561
🇭🇷Rijeka, Croatia
Chiesi Clinical Trial - Site 191563
🇭🇷Rijeka, Croatia
Chiesi Clinical Trial - Site 191553
🇭🇷Sisak, Croatia
Chiesi Clinical Trial - Site 191558
🇭🇷Split, Croatia
Chiesi Clinical Trial - Site 191555
🇭🇷Zadar, Croatia
Chiesi Clinical Trial - Site 191551
🇭🇷Zagreb, Croatia
Chiesi Clinical Trial - Site 191554
🇭🇷Zagreb, Croatia
Chiesi Clinical Trial - Site 191556
🇭🇷Zagreb, Croatia
Chiesi Clinical Trial - Site 191559
🇭🇷Zagreb, Croatia
Chiesi Clinical Trial - Site 191560
🇭🇷Zagreb, Croatia
Chiesi Clinical Trial - Site 203551
🇨🇿Brandýs Nad Labem, Czechia
Chiesi Clinical Trial - Site 203518
🇨🇿Havlíčkův Brod, Czechia
Chiesi Clinical Trial - Site 203501
🇨🇿Jindřichův Hradec, Czechia
Chiesi Clinical Trial - Site 203504
🇨🇿Miroslav, Czechia
Chiesi Clinical Trial - Site 203516
🇨🇿Mladá Boleslav, Czechia
Chiesi Clinical Trial - Site 203517
🇨🇿Měšice, Czechia
Chiesi Clinical Trial - Site 203505
🇨🇿Praha, Czechia
Chiesi Clinical Trial - Site 203507
🇨🇿Praha, Czechia
Chiesi Clinical Trial - Site 203513
🇨🇿Praha, Czechia
Chiesi Clinical Trial - Site 203515
🇨🇿Praha, Czechia
Chiesi Clinical Trial - Site 372553
🇪🇪Narva, Estonia
Chiesi Clinical Trial - Site 372551
🇪🇪Tallinn, Estonia
Chiesi Clinical Trial - Site 372552
🇪🇪Tartu, Estonia
Chiesi Clinical Trial - Site 276505
🇩🇪Berlin, Germany
Chiesi Clinical Trial - Site 276506
🇩🇪Berlin, Germany
Chiesi Clinical Trial - Site 276510
🇩🇪Berlin, Germany
Chiesi Clinical Trial - Site 276511
🇩🇪Berlin, Germany
Chiesi Clinical Trial - Site 276515
🇩🇪Berlin, Germany
Chiesi Clinical Trial - Site 276556
🇩🇪Cottbus, Germany
Chiesi Clinical Trial - Site 276509
🇩🇪Darmstadt, Germany
Chiesi Clinical Trial - Site 276503
🇩🇪Delitzsch, Germany
Chiesi Clinical Trial - Site 276504
🇩🇪Frankfurt Am Main, Germany
Chiesi Clinical Trial - Site 276557
🇩🇪Geesthacht, Germany
Chiesi Clinical Trial - Site 276501
🇩🇪Hamburg, Germany
Chiesi Clinical Trial - Site 276513
🇩🇪Hamburg, Germany
Chiesi Clinical Trial - Site 276514
🇩🇪Hamburg, Germany
Chiesi Clinical Trial - Site 276558
🇩🇪Hannover, Germany
Chiesi Clinical Trial - Site 276517
🇩🇪Koblenz, Germany
Chiesi Clinical Trial - Site 276502
🇩🇪Leipzig, Germany
Chiesi Clinical Trial - Site 276516
🇩🇪Leipzig, Germany
Chiesi Clinical Trial - Site 276551
🇩🇪Leipzig, Germany
Chiesi Clinical Trial - Site 276507
🇩🇪Mainz, Germany
Chiesi Clinical Trial - Site 276508
🇩🇪Munich, Germany
Chiesi Clinical Trial - Site 276518
🇩🇪Peine, Germany
Chiesi Clinical Trial - Site 300506
🇬🇷Athens, Greece
Chiesi Clinical Trial - Site 300504
🇬🇷Chortiátis, Greece
Chiesi Clinical Trial - Site 300501
🇬🇷Heraklion, Greece
Chiesi Clinical Trial - Site 300503
🇬🇷Ioannina, Greece
Chiesi Clinical Trial - Site 300505
🇬🇷Thessaloníki, Greece
Chiesi Clinical Trial - Site 300507
🇬🇷Volos, Greece
Chiesi Clinical Trial - Site 348506
🇭🇺Balassagyarmat, Hungary
Chiesi Clinical Trial - Site 348501
🇭🇺Budapest, Hungary
Chiesi Clinical Trial - Site 348505
🇭🇺Csorna, Hungary
Chiesi Clinical Trial - Site 348512
🇭🇺Edelény, Hungary
Chiesi Clinical Trial - Site 348508
🇭🇺Gödöllő, Hungary
Chiesi Clinical Trial - Site 348509
🇭🇺Monor, Hungary
Chiesi Clinical Trial - Site 348507
🇭🇺Nyíregyháza, Hungary
Chiesi Clinical Trial - Site 348513
🇭🇺Pécs, Hungary
Chiesi Clinical Trial - Site 348552
🇭🇺Sellye, Hungary
Chiesi Clinical Trial - Site 348510
🇭🇺Szeged, Hungary
Chiesi Clinical Trial - Site 348503
🇭🇺Szombathely, Hungary
Chiesi Clinical Trial - Site 348515
🇭🇺Törökbálint, Hungary
Chiesi Clinical Trial - Site 376502
🇮🇱Ashkelon, Israel
Chiesi Clinical Trial - Site 376501
🇮🇱Be'er Sheva, Israel
Chiesi Clinical Trial - Site 376511
🇮🇱Hadera, Israel
Chiesi Clinical Trial - Site 376508
🇮🇱Haifa, Israel
Chiesi Clinical Trial - Site 376510
🇮🇱Haifa, Israel
Chiesi Clinical Trial - Site 376503
🇮🇱Jerusalem, Israel
Chiesi Clinical Trial - Site 376506
🇮🇱Jerusalem, Israel
Chiesi Clinical Trial - Site 376507
🇮🇱Kfar Saba, Israel
Chiesi Clinical Trial - Site 376504
🇮🇱Ramat Gan, Israel
Chiesi Clinical Trial - Site 376509
🇮🇱Tel Aviv, Israel
Chiesi Clinical Trial - Site 484504
🇲🇽Veracruz, Mexico
Chiesi Clinical Trial - Site 528501
🇳🇱Beek, Netherlands
Chiesi Clinical Trial - Site 528504
🇳🇱Breda, Netherlands
Chiesi Clinical Trial - Site 528502
🇳🇱Heerlen, Netherlands
Chiesi Clinical Trial - Site 528505
🇳🇱Leeuwarden, Netherlands
Chiesi Clinical Trial - Site 554504
🇳🇿Christchurch, New Zealand
Chiesi Clinical Trial - Site 554502
🇳🇿Hamilton, New Zealand
Chiesi Clinical Trial - Site 554503
🇳🇿Tauranga, New Zealand
Chiesi Clinical Trial - Site 807555
🇲🇰Bitola, North Macedonia
Chiesi Clinical Trial - Site 807559
🇲🇰Gevgelija, North Macedonia
Chiesi Clinical Trial - Site 807557
🇲🇰Ohrid, North Macedonia
Chiesi Clinical Trial - Site 807553
🇲🇰Shtip, North Macedonia
Chiesi Clinical Trial - Site 807552
🇲🇰Skopje, North Macedonia
Chiesi Clinical Trial - Site 807554
🇲🇰Skopje, North Macedonia
Chiesi Clinical Trial - Site 807556
🇲🇰Skopje, North Macedonia
Chiesi Clinical Trial - Site 616518
🇵🇱Bialystok, Poland
Chiesi Clinical Trial - Site 616504
🇵🇱Giżycko, Poland
Chiesi Clinical Trial - Site 616515
🇵🇱Katowice, Poland
Chiesi Clinical Trial - Site 616522
🇵🇱Katowice, Poland
Chiesi Clinical Trial - Site 616514
🇵🇱Krakow, Poland
Chiesi Clinical Trial - Site 616509
🇵🇱Kraków, Poland
Chiesi Clinical Trial - Site 616511
🇵🇱Kraków, Poland
Chiesi Clinical Trial - Site 616519
🇵🇱Ostrowiec Świętokrzyski, Poland
Chiesi Clinical Trial - Site 616506
🇵🇱Poznań, Poland
Chiesi Clinical Trial - Site 616508
🇵🇱Poznań, Poland
Chiesi Clinical Trial - Site 616501
🇵🇱Sosnowiec, Poland
Chiesi Clinical Trial - Site 616502
🇵🇱Torun, Poland
Chiesi Clinical Trial - Site 616554
🇵🇱Wrocław, Poland
Chiesi Clinical Trial - Site 616503
🇵🇱Łódź, Poland
Chiesi Clinical Trial - Site 616523
🇵🇱Łódź, Poland
Chiesi Clinical Trial - Site 642510
🇷🇴Bacău, Romania
Chiesi Clinical Trial - Site 642551
🇷🇴Braşov, Romania
Chiesi Clinical Trial - Site 642506
🇷🇴Cluj-Napoca Cluj, Romania
Chiesi Clinical Trial - Site 642508
🇷🇴Cluj-Napoca Cluj, Romania
Chiesi Clinical Trial - Site 642502
🇷🇴Cluj-Napoca, Romania
Chiesi Clinical Trial - Site 642504
🇷🇴Cluj-Napoca, Romania
Chiesi Clinical Trial - Site 642554
🇷🇴Cluj-Napoca, Romania
Chiesi Clinical Trial - Site 642512
🇷🇴Cluj, Romania
Chiesi Clinical Trial - Site 642501
🇷🇴Constanţa, Romania
Chiesi Clinical Trial - Site 642509
🇷🇴Craiova, Romania
Chiesi Clinical Trial - Site 642511
🇷🇴Craiova, Romania
Chiesi Clinical Trial - Site 642514
🇷🇴Iaşi, Romania
Chiesi Clinical Trial - Site 642503
🇷🇴Oradea, Romania
Chiesi Clinical Trial - Site 642513
🇷🇴Resca, Romania
Chiesi Clinical Trial - Site 642507
🇷🇴Timisoara, Romania
Chiesi Clinical Trial - Site 642515
🇷🇴Timisoara, Romania
Chiesi Clinical Trial - Site 642505
🇷🇴Timişoara, Romania
Chiesi Clinical Trial - Site 643517
🇷🇺Kazan, Russian Federation
Chiesi Clinical Trial - Site 643513
🇷🇺Moscow, Russian Federation
Chiesi Clinical Trial - Site 643528
🇷🇺Moscow, Russian Federation
Chiesi Clinical Trial - Site 688569
🇷🇸Belgrade, Serbia
Chiesi Clinical Trial - Site 688570
🇷🇸Jagodina, Serbia
Chiesi Clinical Trial - Site 688556
🇷🇸Kragujevac, Serbia
Chiesi Clinical Trial - Site 688562
🇷🇸Leskovac, Serbia
Chiesi Clinical Trial - Site 688554
🇷🇸Niš, Serbia
Chiesi Clinical Trial - Site 688568
🇷🇸Niš, Serbia
Chiesi Clinical Trial - Site 688567
🇷🇸Pančevo, Serbia
Chiesi Clinical Trial - Site 688560
🇷🇸Paraćin, Serbia
Chiesi Clinical Trial - Site 688551
🇷🇸Sombor, Serbia
Chiesi Clinical Trial - Site 688564
🇷🇸Sremska Kamenica, Serbia
Chiesi Clinical Trial - Site 688566
🇷🇸Sremska Kamenica, Serbia
Chiesi Clinical Trial - Site 688571
🇷🇸Sremska Mitrovica, Serbia
Chiesi Clinical Trial - Site 688563
🇷🇸Užice, Serbia
Chiesi Clinical Trial - Site 688565
🇷🇸Valjevo, Serbia
Chiesi Clinical Trial - Site 703501
🇸🇰Bardejov, Slovakia
Chiesi Clinical Trial - Site 703503
🇸🇰Košice, Slovakia
Chiesi Clinical Trial - Site 703502
🇸🇰Spišská Nová Ves, Slovakia
Chiesi Clinical Trial - Site 724503
🇪🇸Barcelona, Spain
Chiesi Clinical Trial - Site 724501
🇪🇸Cordoba, Spain
Chiesi Clinical Trial - Site 724505
🇪🇸Madrid, Spain
Chiesi Clinical Trial - Site 724551
🇪🇸Madrid, Spain
Chiesi Clinical Trial - Site 724504
🇪🇸Majadahonda, Spain
Chiesi Clinical Trial - Site 724502
🇪🇸Zaragoza, Spain
Chiesi Clinical Trial - Site 792512
🇹🇷Adana, Turkey
Chiesi Clinical Trial - Site 792510
🇹🇷Bornova, Turkey
Chiesi Clinical Trial - Site 792507
🇹🇷Istanbul, Turkey
Chiesi Clinical Trial - Site 792514
🇹🇷Kocaeli, Turkey
Chiesi Clinical Trial - Site 792513
🇹🇷Mersin, Turkey
Chiesi Clinical Trial - Site 792506
🇹🇷Pamukkale, Turkey
Chiesi Clinical Trial - Site 792508
🇹🇷Pendik, Turkey
Chiesi Clinical Trial - Site 792511
🇹🇷Yenişehir, Turkey
Chiesi Clinical Trial - Site 792551
🇹🇷Çanakkale, Turkey
Chiesi Clinical Trial - Site 804522
🇺🇦Dnipro, Ukraine
Chiesi Clinical Trial - Site 804502
🇺🇦Ivano-Frankivs'k, Ukraine
Chiesi Clinical Trial - Site 804504
🇺🇦Kharkiv, Ukraine
Chiesi Clinical Trial - Site 804506
🇺🇦Kharkiv, Ukraine
Chiesi Clinical Trial - Site 804509
🇺🇦Kharkiv, Ukraine
Chiesi Clinical Trial - Site 804505
🇺🇦Kharkov, Ukraine
Chiesi Clinical Trial - Site 804503
🇺🇦Kherson, Ukraine
Chiesi Clinical Trial - Site 804511
🇺🇦Kiev, Ukraine
Chiesi Clinical Trial - Site 804520
🇺🇦Kremenchuk, Ukraine
Chiesi Clinical Trial - Site 804501
🇺🇦Kyiv, Ukraine
Chiesi Clinical Trial - Site 804508
🇺🇦Kyiv, Ukraine
Chiesi Clinical Trial - Site 804512
🇺🇦Kyiv, Ukraine
Chiesi Clinical Trial - Site 804516
🇺🇦Kyiv, Ukraine
Chiesi Clinical Trial - Site 804518
🇺🇦Kyiv, Ukraine
Chiesi Clinical Trial - Site 804521
🇺🇦Kyiv, Ukraine
Chiesi Clinical Trial - Site 804527
🇺🇦Odessa, Ukraine
Chiesi Clinical Trial - Site 804507
🇺🇦Poltava, Ukraine
Chiesi Clinical Trial - Site 804515
🇺🇦Vinnytsia, Ukraine
Chiesi Clinical Trial - Site 804517
🇺🇦Vinnytsia, Ukraine
Chiesi Clinical Trial - Site 804528
🇺🇦Zaporizhia, Ukraine
Chiesi Clinical Trial - Site 826510
🇬🇧Belfast, United Kingdom
Chiesi Clinical Trial - Site 826509
🇬🇧Bradford, United Kingdom
Chiesi Clinical Trial - Site 826511
🇬🇧London, United Kingdom
Chiesi Clinical Trial - Site 826512
🇬🇧Rochdale, United Kingdom
Chiesi Clinical Trial - Site 40504
🇦🇹Grieskirchen, Austria
Chiesi Clinical Trial - Site 40501
🇦🇹Linz, Austria
Chiesi Clinical Trial - Site 840635
🇺🇸Andalusia, Alabama, United States
Chiesi Clinical Trial - Site 840614
🇺🇸Foley, Alabama, United States
Chiesi Clinical Trial - Site 840670
🇺🇸Guntersville, Alabama, United States
Chiesi Clinical Trial - Site 840720
🇺🇸Mobile, Alabama, United States
Chiesi Clinical Trial - Site 840643
🇺🇸Saraland, Alabama, United States
Chiesi Clinical Trial - Site 840638
🇺🇸Phoenix, Arizona, United States
Chiesi Clinical Trial - Site 840684
🇺🇸Conway, Arkansas, United States
Chiesi Clinical Trial - Site 840675
🇺🇸Laguna Hills, California, United States
Chiesi Clinical Trial - Site 840666
🇺🇸Los Angeles, California, United States
Chiesi Clinical Trial - Site 840511
🇺🇸Newport Beach, California, United States
Chiesi Clinical Trial - Site 840680
🇺🇸Northridge, California, United States
Chiesi Clinical Trial - Site 840605
🇺🇸Northridge, California, United States
Chiesi Clinical Trial - Site 840700
🇺🇸Pomona, California, United States
Chiesi Clinical Trial - Site 840531
🇺🇸Westminster, California, United States
Chiesi Clinical Trial - Site 840636
🇺🇸Centennial, Colorado, United States
Chiesi Clinical Trial - Site 840688
🇺🇸Lakewood, Colorado, United States
Chiesi Clinical Trial - Site 840735
🇺🇸Brooksville, Florida, United States
Chiesi Clinical Trial - Site 840513
🇺🇸Chiefland, Florida, United States
Chiesi Clinical Trial - Site 840652
🇺🇸Clearwater, Florida, United States
Chiesi Clinical Trial - Site 840569
🇺🇸Clearwater, Florida, United States
Chiesi Clinical Trial - Site 840545
🇺🇸Coral Gables, Florida, United States
Chiesi Clinical Trial - Site 840603
🇺🇸Cutler Bay, Florida, United States
Chiesi Clinical Trial - Site 840587
🇺🇸Cutler Bay, Florida, United States
Chiesi Clinical Trial - Site 840568
🇺🇸Cutler Bay, Florida, United States
Chiesi Clinical Trial - Site840539
🇺🇸Daytona Beach, Florida, United States
Chiesi Clinical Trial - Site 840554
🇺🇸DeBary, Florida, United States
Chiesi Clinical Trial - Site 840625
🇺🇸Doral, Florida, United States
Chiesi Clinical Trial - Site 840572
🇺🇸Doral, Florida, United States
Chiesi Clinical Trial - Site 840637
🇺🇸Hialeah Gardens, Florida, United States
Chiesi Clinical Trial - Site 840685
🇺🇸Hialeah, Florida, United States
Chiesi Clinical Trial - Site 840504
🇺🇸Hialeah, Florida, United States
Chiesi Clinical Trial - Site 840639
🇺🇸Hialeah, Florida, United States
Chiesi Clinical Trial - Site 840582
🇺🇸Hialeah, Florida, United States
Chiesi Clinical Trial - Site 840617
🇺🇸Hialeah, Florida, United States
Chiesi Clinical Trial - Site 840514
🇺🇸Hialeah, Florida, United States
Chiesi Clinical Trial - Site 840509
🇺🇸Hollywood, Florida, United States
Chiesi Clinical Trial - Site 840730
🇺🇸Hollywood, Florida, United States
Chiesi Clinical Trial - Site 840565
🇺🇸Homestead, Florida, United States
Chiesi Clinical Trial - Site 840674
🇺🇸Loxahatchee Groves, Florida, United States
Chiesi Clinical Trial - Site 840732
🇺🇸Melbourne, Florida, United States
Chiesi Clinical Trial - Site 840506
🇺🇸Miami Gardens, Florida, United States
Chiesi Clinical Trial - Site 840608
🇺🇸Miami Lakes, Florida, United States
Chiesi Clinical Trial - Site 840624
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840596
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840556
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840602
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840507
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840519
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840505
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840644
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840557
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840588
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840618
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840525
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840656
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840622
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840537
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840691
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840503
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840694
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840630
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840524
🇺🇸Orlando, Florida, United States
Chiesi Clinical Trial - Site 840563
🇺🇸Orlando, Florida, United States
Chiesi Clinical Trial - Site 840702
🇺🇸Pembroke Pines, Florida, United States
Chiesi Clinical Trial - Site 840502
🇺🇸Pembroke Pines, Florida, United States
Chiesi Clinical Trial - Site 840550
🇺🇸Pembroke Pines, Florida, United States
Chiesi Clinical Trial - Site 840527
🇺🇸Pompano Beach, Florida, United States
Chiesi Clinical Trial - Site 840699
🇺🇸Saint Petersburg, Florida, United States
Chiesi Clinical Trial - Site 840697
🇺🇸Saint Petersburg, Florida, United States
Chiesi Clinical Trial - Site 840654
🇺🇸South Miami, Florida, United States
Chiesi Clinical Trial - Site 840567
🇺🇸Tampa, Florida, United States
Chiesi Clinical Trial - Site 840632
🇺🇸Winter Park, Florida, United States
Chiesi Clinical Trial - Site 840542
🇺🇸Adairsville, Georgia, United States
Chiesi Clinical Trial - Site 840728
🇺🇸College Park, Georgia, United States
Chiesi Clinical Trial - Site 840717
🇺🇸Columbus, Georgia, United States
Chiesi Clinical Trial - Site 840710
🇺🇸Cordele, Georgia, United States
Chiesi Clinical Trial - Site 840689
🇺🇸East Point, Georgia, United States
Chiesi Clinical Trial - Site 840726
🇺🇸Stonecrest, Georgia, United States
Chiesi Clinical Trial - Site 840564
🇺🇸Valdosta, Georgia, United States
Chiesi Clinical Trial - Site 840724
🇺🇸Muncie, Indiana, United States
Chiesi Clinical Trial - Site 840672
🇺🇸Zachary, Louisiana, United States
Chiesi Clinical Trial - Site 840645
🇺🇸Annapolis, Maryland, United States
Chiesi Clinical Trial - Site 840661
🇺🇸Baltimore, Maryland, United States
Chiesi Clinical Trial - Site 840707
🇺🇸North Dartmouth, Massachusetts, United States
Chiesi Clinical Trial - Site 840657
🇺🇸Troy, Michigan, United States
Chiesi Clinical Trial - Site 840658
🇺🇸Port Gibson, Mississippi, United States
Chiesi Clinical Trial - Site 840641
🇺🇸Saint Charles, Missouri, United States
Chiesi Clinical Trial - Site 840714
🇺🇸Saint Louis, Missouri, United States
Chiesi Clinical Trial - Site 840541
🇺🇸Saint Louis, Missouri, United States
Chiesi Clinical Trial - Site 840669
🇺🇸Saint Louis, Missouri, United States
Chiesi Clinical Trial - Site 840686
🇺🇸Omaha, Nebraska, United States
Chiesi Clinical Trial - Site 840703
🇺🇸Henderson, Nevada, United States
Chiesi Clinical Trial - Site 840529
🇺🇸Las Vegas, Nevada, United States
Chiesi Clinical Trial - Site 840701
🇺🇸North Las Vegas, Nevada, United States
Chiesi Clinical Trial - Site 840722
🇺🇸Bayonne, New Jersey, United States
Chiesi Clinical Trial - Site 840626
🇺🇸Bronx, New York, United States
Chiesi Clinical Trial - Site 840604
🇺🇸Bronx, New York, United States
Chiesi Clinical Trial - Site 840667
🇺🇸Buffalo, New York, United States
Chiesi Clinical Trial - Site 840678
🇺🇸New Windsor, New York, United States
Chiesi Clinical Trial - Site 840520
🇺🇸New York, New York, United States
Chiesi Clinical Trial - Site 840705
🇺🇸New York, New York, United States
Chiesi Clinical Trial - Site 840664
🇺🇸Charlotte, North Carolina, United States
Chiesi Clinical Trial - Site 840721
🇺🇸Charlotte, North Carolina, United States
Chiesi Clinical Trial - Site 840610
🇺🇸Denver, North Carolina, United States
Chiesi Clinical Trial - Site 840659
🇺🇸Gastonia, North Carolina, United States
Chiesi Clinical Trial - Site 840540
🇺🇸Huntersville, North Carolina, United States
Chiesi Clinical Trial - Site 840523
🇺🇸New Bern, North Carolina, United States
Chiesi Clinical Trial - Site 840708
🇺🇸Shelby, North Carolina, United States
Chiesi Clinical Trial - Site 840621
🇺🇸Winston-Salem, North Carolina, United States
Chiesi Clinical Trial - Site 840627
🇺🇸Cincinnati, Ohio, United States
Chiesi Clinical Trial - Site 840713
🇺🇸Columbus, Ohio, United States
Chiesi Clinical Trial - Site 840647
🇺🇸Dayton, Ohio, United States
Chiesi Clinical Trial - Site 840646
🇺🇸Toledo, Ohio, United States
Chiesi Clinical Trial - Site 840668
🇺🇸Oklahoma City, Oklahoma, United States
Chiesi Clinical Trial - Site 840692
🇺🇸Tulsa, Oklahoma, United States
Chiesi Clinical Trial - Site 840671
🇺🇸Philadelphia, Pennsylvania, United States
Chiesi Clinical Trial - Site 840683
🇺🇸Philadelphia, Pennsylvania, United States
Chiesi Clinical Trial - Site 840578
🇺🇸Anderson, South Carolina, United States
Chiesi Clinical Trial - Site 840592
🇺🇸Charleston, South Carolina, United States
Chiesi Clinical Trial - Site 840528
🇺🇸Fort Mill, South Carolina, United States
Chiesi Clinical Trial - Site 840598
🇺🇸North Charleston, South Carolina, United States
Chiesi Clinical Trial - Site 840696
🇺🇸Rock Hill, South Carolina, United States
Chiesi Clinical Trial - Site 840660
🇺🇸Franklin, Tennessee, United States
Chiesi Clinical Trial - Site 840546
🇺🇸Franklin, Tennessee, United States
Chiesi Clinical Trial - Site 840553
🇺🇸Knoxville, Tennessee, United States
Chiesi Clinical Trial - Site 840535
🇺🇸Baytown, Texas, United States
Chiesi Clinical Trial - Site 840634
🇺🇸Boerne, Texas, United States
Chiesi Clinical Trial - Site 840704
🇺🇸Carrollton, Texas, United States
Chiesi Clinical Trial - Site 840566
🇺🇸Cypress, Texas, United States
Chiesi Clinical Trial - Site 840706
🇺🇸Dallas, Texas, United States
Chiesi Clinical Trial - Site 840716
🇺🇸Houston, Texas, United States
Chiesi Clinical Trial - Site 840698
🇺🇸Houston, Texas, United States
Chiesi Clinical Trial - Site 840574
🇺🇸Kerrville, Texas, United States
Chiesi Clinical Trial - Site 840551
🇺🇸McKinney, Texas, United States
Chiesi Clinical Trial - Site 840575
🇺🇸Mesquite, Texas, United States
Chiesi Clinical Trial - Site 840741
🇺🇸North Richland Hills, Texas, United States
Chiesi Clinical Trial - Site 840663
🇺🇸Pearland, Texas, United States
Chiesi Clinical Trial - Site 840609
🇺🇸Plano, Texas, United States
Chiesi Clinical Trial - Site 840673
🇺🇸San Antonio, Texas, United States
Chiesi Clinical Trial - Site 840681
🇺🇸San Antonio, Texas, United States
Chiesi Clinical Trial - Site 840711
🇺🇸San Antonio, Texas, United States
Chiesi Clinical Trial - Site 840729
🇺🇸San Antonio, Texas, United States
Chiesi Clinical Trial - Site 840597
🇺🇸San Antonio, Texas, United States
Chiesi Clinical Trial - Site 840600
🇺🇸Sherman, Texas, United States
Chiesi Clinical Trial - Site 840552
🇺🇸Sugar Land, Texas, United States
Chiesi Clinical Trial - Site 840526
🇺🇸Tomball, Texas, United States
Chiesi Clinical Trial - Site 840693
🇺🇸Portsmouth, Virginia, United States
Chiesi Clinical Trial - Site 840709
🇺🇸Everett, Washington, United States
Chiesi Clinical Trial - Site 840562
🇺🇸Morgantown, West Virginia, United States
Chiesi Clinical Trial - Site 840532
🇺🇸Greenfield, Wisconsin, United States
Chiesi Clinical Trial - Site 840723
🇺🇸Milwaukee, Wisconsin, United States
Chiesi Clinical Trial - Site 32502
🇦🇷Buenos Aires, Argentina
Chiesi Clinical Trial - Site 32515
🇦🇷Buenos Aires, Argentina
Chiesi Clinical Trial - Site 32565
🇦🇷Buenos Aires, Argentina
Chiesi Clinical Trial - Site 32514
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Chiesi Clinical Trial - Site 32567
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Chiesi Clinical Trial - Site 32510
🇦🇷Ciudad autónoma de Buenos Aires, Argentina
Chiesi Clinical Trial - Site 32507
🇦🇷Ciudad Autónoma de Buenos Aire, Argentina
Chiesi Clinical Trial - Site 32563
🇦🇷Concepción Del Uruguay, Argentina
Chiesi Clinical Trial - Site 32503
🇦🇷Córdoba, Argentina
Chiesi Clinical Trial - Site 32509
🇦🇷Córdoba, Argentina
Chiesi Clinical Trial - Site 32508
🇦🇷Florencio Varela, Argentina
Chiesi Clinical Trial - Site 32501
🇦🇷Florida, Argentina
Chiesi Clinical Trial - Site 32562
🇦🇷Mar Del Plata, Argentina
Chiesi Clinical Trial - Site 32505
🇦🇷Mendoza, Argentina
Chiesi Clinical Trial - Site 32511
🇦🇷Mendoza, Argentina
Chiesi Clinical Trial - Site 32513
🇦🇷Mendoza, Argentina
Chiesi Clinical Trial - Site 32506
🇦🇷Quilmes, Argentina
Chiesi Clinical Trial - Site 32553
🇦🇷Rosario, Argentina
Chiesi Clinical Trial - Site 32512
🇦🇷San Miguel De Tucumán, Argentina
Chiesi Clinical Trial - Site 32551
🇦🇷San Miguel De Tucumán, Argentina
Chiesi Clinical Trial - Site 32561
🇦🇷San Miguel de Tucumán, Argentina
Chiesi Clinical Trial - Site 32564
🇦🇷San Miguel De Tucumán, Argentina
Chiesi Clinical Trial - Site 32566
🇦🇷San Rafael, Argentina
Chiesi Clinical Trial - Site 32556
🇦🇷Santa Fe, Argentina
Chiesi Clinical Trial - Site 40502
🇦🇹Feldbach, Austria
Chiesi Clinical Trial - Site 70558
🇧🇦Trebinje, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 70563
🇧🇦Tuzla, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 70552
🇧🇦Zenica, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 100535
🇧🇬Blagoevgrad, Bulgaria
Chiesi Clinical Trial - Site 100534
🇧🇬Dimitrovgrad, Bulgaria
Chiesi Clinical Trial - Site 100525
🇧🇬Gabrovo, Bulgaria
Chiesi Clinical Trial - Site 100523
🇧🇬Haskovo, Bulgaria
Chiesi Clinical Trial - Site 100533
🇧🇬Kozloduy, Bulgaria
Chiesi Clinical Trial - Site 100527
🇧🇬Lovech, Bulgaria
Chiesi Clinical Trial - Site 100515
🇧🇬Montana, Bulgaria
Chiesi Clinical Trial - Site 100532
🇧🇬Pernik, Bulgaria
Chiesi Clinical Trial - Site 100522
🇧🇬Pleven, Bulgaria
Chiesi Clinical Trial - Site 100529
🇧🇬Plovdiv, Bulgaria
Chiesi Clinical Trial - Site 100537
🇧🇬Razgrad, Bulgaria
Chiesi Clinical Trial - Site 100512
🇧🇬Ruse, Bulgaria
Chiesi Clinical Trial - Site 100516
🇧🇬Ruse, Bulgaria
Chiesi Clinical Trial - Site 100536
🇧🇬Sevlievo, Bulgaria
Chiesi Clinical Trial - Site 100501
🇧🇬Sofia, Bulgaria
Chiesi Clinical Trial - Site 100509
🇧🇬Sofia, Bulgaria
Chiesi Clinical Trial - Site 100514
🇧🇬Sofia, Bulgaria
Chiesi Clinical Trial - Site 100517
🇧🇬Sofia, Bulgaria
Chiesi Clinical Trial - Site 100518
🇧🇬Sofia, Bulgaria
Chiesi Clinical Trial - Site 100530
🇧🇬Sofia, Bulgaria
Chiesi Clinical Trial - Site 100531
🇧🇬Sofia, Bulgaria
Chiesi Clinical Trial - Site 100538
🇧🇬Sofia, Bulgaria
Chiesi Clinical Trial - Site 100524
🇧🇬Stara Zagora, Bulgaria
Chiesi Clinical Trial - Site 100519
🇧🇬Vidin, Bulgaria
Chiesi Clinical Trial - Site 100557
🇧🇬Vidin, Bulgaria
Chiesi Clinical Trial - Site 152506
🇨🇱Concepcion, Chile
Chiesi Clinical Trial - Site 408556
🇰🇷Anyang-si, Korea, Republic of
Chiesi Clinical Trial - Site 408551
🇰🇷Daegu, Korea, Republic of
Chiesi Clinical Trial - Site 408560
🇰🇷Dongjak, Korea, Republic of
Chiesi Clinical Trial - Site 408554
🇰🇷Gwangju, Korea, Republic of
Chiesi Clinical Trial - Site 408559
🇰🇷Haeundae, Korea, Republic of
Chiesi Clinical Trial - Site 408557
🇰🇷Incheon, Korea, Republic of
Chiesi Clinical Trial - Site 408558
🇰🇷Incheon, Korea, Republic of
Chiesi Clinical Trial - Site 408555
🇰🇷Jeonju, Korea, Republic of
Chiesi Clinical Trial - Site 408552
🇰🇷Seoul, Korea, Republic of
Chiesi Clinical Trial - Site 408553
🇰🇷Seoul, Korea, Republic of
Chiesi Clinical Trial - Site 408561
🇰🇷Suwon,Gyeonggi-do, Korea, Republic of
Chiesi Clinical Trial - Site 371557
🇱🇻Balvi, Latvia
Chiesi Clinical Trial - Site 371553
🇱🇻Daugavpils, Latvia
Chiesi Clinical Trial - Site 371554
🇱🇻Daugavpils, Latvia
Chiesi Clinical Trial - Site 371555
🇱🇻Jūrmala, Latvia
Chiesi Clinical Trial - Site 371551
🇱🇻Riga, Latvia
Chiesi Clinical Trial - Site 371552
🇱🇻Riga, Latvia
Chiesi Clinical Trial - Site 371558
🇱🇻Rēzekne, Latvia
Chiesi Clinical Trial - Site 371556
🇱🇻Rīga, Latvia
Chiesi Clinical Trial - Site 484502
🇲🇽Chihuahua, Mexico
Chiesi Clinical Trial - Site 484510
🇲🇽Chihuahua, Mexico
Chiesi Clinical Trial - Site 484505
🇲🇽Cordoba, Mexico
Chiesi Clinical Trial - Site 484506
🇲🇽Cuauhtémoc, Mexico
Chiesi Clinical Trial - Site 484501
🇲🇽Guadalajara, Mexico
Chiesi Clinical Trial - Site 484507
🇲🇽Guadalajara, Mexico
Chiesi Clinical Trial - Site 484509
🇲🇽Guadalajara, Mexico
Chiesi Clinical Trial - Site 484503
🇲🇽Monterrey, Mexico
Chiesi Clinical Trial - Site 484511
🇲🇽Monterrey, Mexico
Chiesi Clinical Trial - Site 643516
🇷🇺Nizhniy Novgorod, Russian Federation
Chiesi Clinical Trial - Site 643503
🇷🇺Odintsovskiy, Russian Federation
Chiesi Clinical Trial - Site 643505
🇷🇺Saint Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643506
🇷🇺Saint Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643508
🇷🇺Saint Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643511
🇷🇺Saint Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643514
🇷🇺Saint Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643519
🇷🇺Saint Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643531
🇷🇺Saint Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643510
🇷🇺Saint-Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643512
🇷🇺Saint-Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643520
🇷🇺Saint-Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643504
🇷🇺Sankt-Peterburg, Russian Federation
Chiesi Clinical Trial - Site 643515
🇷🇺Saratov, Russian Federation
Chiesi Clinical Trial - Site 643525
🇷🇺Saratov, Russian Federation
Chiesi Clinical Trial - Site 643521
🇷🇺Ulyanovsk, Russian Federation
Chiesi Clinical Trial - Site 643502
🇷🇺Voronezh, Russian Federation
Chiesi Clinical Trial - Site 643524
🇷🇺Vsevolozhsk, Russian Federation
Chiesi Clinical Trial - Site 643507
🇷🇺Yaroslavl, Russian Federation
Chiesi Clinical Trial - Site 643518
🇷🇺Yaroslavl, Russian Federation
Chiesi Clinical Trial - Site 688552
🇷🇸Belgrade, Serbia
Chiesi Clinical Trial - Site 688553
🇷🇸Belgrade, Serbia
Chiesi Clinical Trial - Site 688555
🇷🇸Belgrade, Serbia
Chiesi Clinical Trial - Site 688557
🇷🇸Belgrade, Serbia
Chiesi Clinical Trial - Site 688558
🇷🇸Belgrade, Serbia
Chiesi Clinical Trial - Site 688559
🇷🇸Belgrade, Serbia
Chiesi Clinical Trial - Site 688561
🇷🇸Belgrade, Serbia