Effects of rTMS on Human Brain Activity Measured With fMRI
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Human Brain Activity
- Sponsor
- Duke University
- Enrollment
- 27
- Locations
- 1
- Primary Endpoint
- Activation of Cortical Networks During a Visual Motion Task.
- Status
- Terminated
- Last Updated
- 3 years ago
Overview
Brief Summary
This project investigates the effects of repetitive transcranial magnetic stimulation (rTMS) on neural circuits as a function of spatiotemporal parameters and brain state in order to better understand why the method works and how to improve its efficacy. Leveraging our expertise in application of TMS methodology during concurrent single neuron recording techniques in non-human primates and imaging and scalp potential techniques in humans, the investigators aim to resolve three interlocking problems in the design and application of rTMS: stimulation frequency, spatial targeting, and interactions with brain state.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age between 18-
- •Use of effective method of birth control for women of childbearing capacity.
- •Willing to provide informed consent.
Exclusion Criteria
- •Current or recent (within the past 6 months) of substance abuse or dependence, excluding nicotine and caffeine (urine test).
- •Current serious medical illness (self report).
- •History of seizure except those therapeutically induced by ECT (childhood febrile seizures are acceptable and these subjects may be included in the study), history of epilepsy in self or first degree relatives, stroke, brain surgery, head injury, cranial metal implants, known structural brain lesion, devices that may be affected by rTMS or MRI (pacemaker, medication pump, cochlear implant, implanted brain stimulator); \[TMS Adult Safety Screening (TASS) form\].
- •Subjects are unable or unwilling to give informed consent.
- •Diagnosed any Axis I DSM-IV disorder (MINI, DSM-IV)
- •Subjects with a clinically defined neurological disorder including, but not limited to:
- •Any condition likely to be associated with increased intracranial pressure
- •Space occupying brain lesion.
- •History of stroke.
- •Transient ischemic attack within two years.
Outcomes
Primary Outcomes
Activation of Cortical Networks During a Visual Motion Task.
Time Frame: during each TMS session, up to 3 hours
Acute effect of a rTMS session on fMRI activation during a motion task, as measured by the change in BOLD signal
Reaction Time
Time Frame: during each TMS session, up to 3 hours
Acute effect of a rTMS session on the performance for a motion task, as measured by reaction time (in ms)
Motion Perception Accuracy
Time Frame: during each TMS session, up to 3 hours
Acute effect of a rTMS session on the performance for a motion task, as measured by accuracy (in percentage of correct responses)