NCT01682382已完成不适用
Collection of Whole Blood Specimens and Buccal Swabs From Subjects Diagnosed With CNV AMD, Dry AMD, and Age-Matched Controls to Assess the Association of Genetic Variants in Complement Factor H With Risk of Progression to CNV.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Association between a genetic variant in the CFH gene and risk of progression to CNV
研究概览
简要总结
Subjects with wet AMD, dry AMD, and age-matched controls will undergo routine occular measurements, will provide a blood and cheek cell sample, and will have macular pigment optical density (MPOD) measured to determine if there is an association between genetics, MPOD and the risk of progression to wet AMD.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •subject is diagnosed with either CNV, dry AMD or is an age-matched control
- •self reported as non-Hispanic Caucasian
- •60 years of age or older
- •provides signed and dated informed consent
- •agrees to provide 10 mL of whole blood and two buccal swabs
排除标准
- •previous donation under this protocol
结局指标
主要结局
Association between a genetic variant in the CFH gene and risk of progression to CNV
时间窗: Baseline
DNA extracted from blood and buccal cells collected from subjects with either CNV, dry AMD, and age-matched controls will be analyzed to investigate a genetic variant in the CFH gene and its association with risk of progression to CNV
次要结局
- Genetic correlation between MPOD and risk of progression to CNV(baseline)
研究者
研究点 (1)
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