Research of the Effects of Pectoralis Nerve Block II and Erector Spina Plan Block in Breast Cancer Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Anesthesia
- Sponsor
- Ondokuz Mayıs University
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- Opioid consumption in the first 24 hours after surgery
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
This study evaluates the analgesic effects of pectoralis nerve block (PECS II) and erector spinae plane block (ESP) in patients having segmental mastectomy and sentinel lymph node biopsy (SLNB). Each one-third of patients will have ESP block and pectoralis nerve block (PECS II) 30 min before general anesthesia , while other one-third of patients will have only general anesthesia.
Detailed Description
It has been proven that PECS II and ESP both supply effective analgesia in the first 24 hours after mastectomy. But they do so by different mechanishms. This study is to survey that ESP and PECS II may supply acute and chronic analgesia by reducing pain scores in the first 24 hours and 3 months after the surgery, also the comparison of the analgesic activity among themselves for acute / chronic pain and opioid consumption will be searched. In this study patients are divided into three groups. Patients in PECS group will have PECS II block in a separate section from the operating rooms (PNB practice room). In addition, patient controlled analgesia (PCA) will be used in the first 24 hours postoperatively. Patients in ESP group will have ESP block in a separate section from the operating rooms (PNB practice room). In addition, PCA will be used in the first 24 hours postoperatively. Patients in control group will not be performed nerve block. Only general anesthesia (GA) will be performed in the operation room. In addition, PCA will be used in the first 24 hours postoperatively.
Investigators
Caner Genç
Medical Doctor
Ondokuz Mayıs University
Eligibility Criteria
Inclusion Criteria
- •ASA 1-2 patients between the age of 18-65, scheduled for elective unilateral segmental mastectomy + sentinel lymph node biopsy
Exclusion Criteria
- •Age \<18 or\> 65, ASA 3-4 patients
- •Obesity (\> 100 kg, BMI\> 35 kg / m2)
- •Patients undergoing bilateral mastectomy
- •Pregnancy
- •Contraindication of regional anesthesia (coagulopathy, abnormal INR, thrombocytopenia, infection at the injection site)
- •Serious renal, cardiac, hepatic disease
- •Hypersensitivity to local anesthetics or a history of allergy
- •Patients with a history of opioid use longer than four weeks
- •Patients with psychiatric disorders or communication difficulties
- •Patients with chest deformity
Outcomes
Primary Outcomes
Opioid consumption in the first 24 hours after surgery
Time Frame: 1 day
Morphine consumption in the first 24 hours will be counted by IV PCA. Patients will be able to request opioids via PCA device when the vas score is 4 points or more when the arm is in the resting position.
Secondary Outcomes
- Remifentanil consumption during the surgery(During the surgery)
- Post-operative acute pain(1 day)
- The incidences of post-operative nausea and vomiting (PONV)(1 day)
- The number of patient required rescue analgesia(1 day)
- Post-operative chronic pain(3. month after surgery)