Acute effects of chlorogenic acid on endothelial function, blood pressure and nitric oxide (NO) status in healthy men and wome

Not Applicable

Completed

• Conditions: Cardiovascular disease; Cardiovascular - Coronary heart disease; Diet and Nutrition - Other diet and nutrition disorders; Cardiovascular - Hypertension

• Registration Number: ACTRN12611000467932
• Lead Sponsor: niversity of Western Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-05-05
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Men and women aged 18 to 65 years

Exclusion Criteria

1. Current or recent (<12 months) smoking
2. Body mass index < 18 or > 35 kg/m2,
3. History of cardiovascular or peripheral vascular disease,
4. A systolic blood pressure below 100 or above 160 mmHg
5. A diastolic blood pressure below 50 or above 100 mmHg
6. Diagnosed diabetes, and non-diabetic individuals with 7.Fasting plasma glucose concentrations greater than or equal to 5.5 mmol/L,
8. A psychiatric illness,
9. Other major illnesses such as cancer,
10. Current or recent (within previous 6 months) significant 11. Weight loss or gain (> 6% of body weight),
12. Reported lactating, pregnant or wishing to become pregnant during the study,
13. Alcohol intake > 210 g per wk for women and > 280 g per wk for men, and
14. Inability or unwillingness to consume foods/beverages provided.
15. Unwillingness to stop the use of supplements 24 hours prior to the testing day.
16. Have any health conditions that would affect food metabolism including the following: food allergies, kidney disease, liver disease and/or gastrointestinal diseases (e.g Irritable bowel syndrome, celiac disease, peptic ulcers)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
itric oxide status assessed by measuring plasma S-nitrosothiols using a NO analyser[Baseline and 2 hours after treatment]

Secondary Outcome Measures

Name	Time	Method
Endothelial function assessed by measuring flow mediated dilatation of the brachial artery using ultrasound[Baseline and 90 min after treatment];Blood pressure measured using an automated blood pressure monitor[Baseline and 60,90,120 and 150 min after treatment]