Daily Undulating Periodization Methods With Parkinson's Disease

Not Applicable

Completed

• Conditions: Parkinson Disease; Weight-Lifting Exercise Program

• Registration Number: NCT03867877
• Lead Sponsor: University of Miami

Brief Summary

Compare periodized (cyclic) resistance training with and without motor training specific to activities of daily living.

Detailed Description

This study will look at how well two different daily undulating training programs (hypertrophy-strength-power training, versus strength-power-functional training) improve participants' physical functions. All testing procedures will take place at the Max Orovitz Laboratory on the Coral Gables campus. This study will involve a 1-week baseline testing phase, a 2-week familiarization phase, a 9-week intervention phase, and a 1-week post-testing window where subjects must report to the lab for 2 sessions.

Study Timeline

• Study Start: 2019-01-11
• Study First Submitted: 2019-03-06
• Study First Submitted QC: 2019-03-06
• Study First Posted: 2019-03-08
• Status Verified: 2019-07
• Primary Completion: 2019-07-09
• Study Completion: 2019-07-09
• Last Update Submitted: 2019-07-10
• Last Update Posted: 2019-07-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Hoehn & Yahr Classification of Disability, stage 1-3
• can ambulate with or without an assistive device for at least 50 feet
• able to get up and down from the floor with minimal assistance
• has a score of 24 or above on the Folstein Mini-Mental State Exam

Exclusion Criteria

• Greater than Stage 3 on the Hoehn & Yahr Classification of Disability
• decline in immune function such as pneumonia or systemic infection
• progressive degenerative disease besides PD
• spinal fusion or other orthopedic surgery in the past six months
• mental disease/psychosis such as dementia
• greater than minimal assistance required for gait and transfers
• inability to make regular time commitments to the scheduled training sessions
• participation in resistance training on a regular basis within the past six months
• inability to provide consent
• pregnancy
• a prisoner

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Strength Test	30 minutes	The participant will perform the concentric phase within the limits of the participant's own specific range of motion for each joint/movement tested over 2 second periods. The tester will gradually increase the resistance for each repetition until the participant are not able to move the lever arm one time through the full range of motion. The participant will be asked how hard the test felt after each repetition and each muscle group will be finished in a maximum of seven repetitions.
Gait Test	10 minutes	The gait test will be a standard 10 meter gait test at usual (two trials) and maximum (2 trials) speed. The participant will be timed using a stopwatch.
Timed Up and Go Test (TUG)	2-4 minutes	The participant will be asked to stand up from a standard chair with a seat height of between 40 and 50 centimeters, walk a 3-meter distance at a normal pace, turn, walk back to the chair, and sit down. The test takes approximately 2-4 minutes to complete with instructions.
Seated Medicine Ball Chest Throw	10 minutes	Participants will be seated in an armless chair with their backs against the seat back and feet flat on the floor. They will then asked to throw a 3kg medicine ball as far as they can. Subjects are allowed to practice as many times as they want. Two trails will be performed with and a one minute rest will be provided.
30 Second Sit-to-Stand Power Test	5 minutes	The participant will be asked to sit in a chair with their feet flat on the ground and their arms placed across their chest. They will stand fully as many times times as they can in 30 seconds.
Mini Best test	15 minutes	This is a 14-item test designed to measure the participant's balance while standing still and moving. The test takes about 15-20 minutes and includes the following activities: * Sit to stand; * Rise to toes; * Stand on one leg; * Compensatory stepping correction - forward; * Compensatory stepping correction - backward; * Compensatory stepping correction - lateral; * Stance (feet together); eyes open, firm surface; * Stance (feet together); eyes closed, foam surface; * Incline eyes closed; * Change in speed; * Walk with head turns - horizontal; * Walk with pivot turns; * Step over obstacles; * Timed up and go (TUG) with and without dual task

Trial Locations

Locations (2)

Max Orovitz Laboratories; 🇺🇸 Coral Gables, Florida, United States

Max Orovitz Laboratory; 🇺🇸 Coral Gables, Florida, United States