Influence of Consecutive Strength- and Endurance Regimes on the Myonuclear Domain and Satellite Cell in the M. Vastus Lateralis of Old Healthy Men

Not Applicable

Completed

• Conditions: Regeneration Potential of Healthy Old Men in Terms of Satellite Cell Activation
• Interventions: Procedure: Training

• Registration Number: NCT01905345
• Lead Sponsor: University of Zurich

Brief Summary

Randomised training intervention.

Influence of consecutive training regime on the impact of the myonuclear domain and satellite cell

Sarcopenia

Despite that the muscle mass can be positively influenced by training, the loading with high weights and/or to the total exhaustion is for many old persons not possible.

Therefore we aim to enhance the myonuclei in the muscle fiber of old male subjects in a first phase by endurance training, in order to promote a more effective muscle growth in a second phase by resistance exercise.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2013-07-16
• Study First Submitted QC: 2013-07-18
• Study First Posted: 2013-07-23
• Study Start: 2013-08
• Primary Completion: 2015-12
• Status Verified: 2017-08
• Study Completion: 2017-08
• Last Update Submitted: 2017-08-04
• Last Update Posted: 2017-08-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 30

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Resistance Training	Training	resistance exercise (12wk)
Endurance and Resistance Training	Training	Endurance and resistance exercise
Resistance and resistance Training	Training	resistance exercise (24 wk)

Primary Outcome Measures

Name	Time	Method
Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain [um^2], myonuclear number [%] in response to consecutive training regimes	participants will be followed for the duration of training period, an expected average of 7 months	Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain \[um\^2\], myonuclear number \[%\] in response to consecutive training regimes

Trial Locations

Locations (1)

University Hospital Zurich, Division of Neurology; 🇨🇭 Zurich, ZH, Switzerland