Effect of a Nasal Bolus Allergen Challenge on Inflammatory Markers
Phase 1
Completed
- Conditions
- Seasonal Allergic Rhinitis
- Registration Number
- NCT00483353
- Lead Sponsor
- Pfizer
- Brief Summary
The current study will investigate nasal inflammatory markers obtained by filter paper collection techniques, in subjects with allergic rhinitis, determining the most appropriate time points and handling conditions, prior to running a larger study with subjects with allergic rhinitis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 6
Inclusion Criteria
- Male or female subjects with allergic rhinitis, that have a positive skin prick response to Phleum pratense.
Exclusion Criteria
- Subjects with a history of asthma. Current smokers, or recent ex-smokers and subjects that have had a respiratory tract infection in the previous 4 weeks.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Post allergen challenge nasal inflammatory markers at 1, 5, 15, 30, 45 min, 1, 2, 3, 4, 5, 6, 7, 8 hours post allergen challenge.
- Secondary Outcome Measures
Name Time Method Post allergen challenge effects on acoustic rhinometry and symptoms at 16, 31, 45 min, 1, 2, 3, 4, 5, 6, 7, 8 hours post allergen challenge.
Trial Locations
- Locations (1)
Pfizer Investigational Site
🇬🇧London, England, United Kingdom