Clinical and Economic Effectiveness of Pharmacogenomic (PGx) Testing in Patients With Polypharmacy
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 600
- 试验地点
- 2
- 主要终点
- Healthcare expenditures
研究概览
简要总结
The purpose of this study is to determine the clinical and economic effectiveness of a pharmacogenomic (PGx) approach to prescribing medications in patients with high-risk polypharmacy in an integrated healthcare delivery system.
Investigators hypothesize that patients who receive the RightMed® PGx test from OneOme, LLC with subsequent counseling of their prescribers by a study pharmacist, as needed, on the appropriateness of their prescribed medications will experience lower one-year follow-up healthcare utilization and expenditures compared to control patients who receive usual care.
详细描述
The purpose of this study is to determine the clinical and economic effectiveness of a pharmacogenomic (PGx) approach to prescribing medications in patients with high-risk polypharmacy in an integrated healthcare delivery system.
Investigators hypothesize that patients who receive the RightMed® PGx test from OneOme, LLC with subsequent counseling of their prescribers by a study pharmacist, as needed, on the appropriateness of their prescribed medications will experience lower one-year follow-up healthcare utilization and expenditures compared to control patients who receive usual care.
Primary Objectives:
- Healthcare expenditures: 6- and 12-month changes in total healthcare expenditures from the Kaiser Permanente Colorado (KPCO) perspective
- Healthcare utilization: 6- and 12-month changes in hospitalizations, emergency room visits, medical office visits, and telephone encounters
Secondary Objectives:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-79 years of age
- •Days supply of 5+ medications with 2+ advisable for PGx on the RightMed test
- •English or Spanish speaker
- •Current KPCO member
- •Dispensing 1 med (for advisable for PGx) in the 90 days prior with no dispensing in the previous six months -or- daily dose change (up or down) in the 90 days
- •Prescriber from Smoky Hill, Westminster, Hidden Lake, Skyline, East Denver, or Lakewood clinics
- •Available email address -
排除标准
- •Pregnant (HCG+ test in the previous 9 months)
- •A live birth in the previous 24 months
- •SNF or hospice stay in the previous 1 month
- •Hospitalization in previous 14 days
- •Diagnosis of dementia, delerium, alzheimer's, or parkinson's in the previous 6 months
- •On the KPCO No Contact List -
结局指标
主要结局
Healthcare expenditures
时间窗: 6 and 12 months after consent
Changes in mean/median total healthcare expenditures from the KPCO perspective
Healthcare utilization
时间窗: 6 and 12 months after consent
Changes in the proportion with at least one and mean/median count of hospitalization, emergency room visit, medical office visit, and telephone encounter
次要结局
- Medication changes(6 months after consent)
- Medication congruence(6 months after consent)
- Pharmacy expenditures(6 and 12 months after consent)
- Medication adherence(6 and 12 months after consent)