The effect of two dosages of theobromine and caffeine on mood and cognition in healthy subjects
- Conditions
- stemming en cognitieNAP
- Registration Number
- NL-OMON33090
- Lead Sponsor
- nilever
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 28
Age at start of the study >= 18 and <= 55 years
Being female
Body mass index (BMI) >= 18.5 and <= 30.0 kg/m2.
Reported alcohol consumption < 14 alcohol units/week
Agreeing to be informed about medically relevant personal test-results
Informed consent signed
Willing to refrain from caffeine and theobromine for 28 hours, from 8 p.m. on the day prior to the measurement day until the end of the measurement day (0:00 - midnight)
Apparently healthy: no reported current or previous diseases or disorders which might effect study measurements assessed by Research physician
Consuming animal foods products (gelatine).
Consumes dark chocolate at least once in a month
Having a general practitioner (GP)
Being an Unilever employee
Consumes more than 250 mg caffeine daily
Using or planning to use any medically prescribed diet or weight-loss diet or making any attempt to control diet at screening and during the entire study.
Reported intense sporting activities > 10 h/w
Subjects who undergoing medical treatment that may interfere with the study outcome.
Use of systemic antibiotics in the period of 3 months prior to the study
Reported participation in another biomedical study 1 month before the start or during the study.
Reported intolerance or allergy for one of test products or standardized meal
The habit of smoking during the past half year or using nicotine containing medicines during the past month
Reported lactating (or lactating < 6 weeks ago), pregnant (or pregnant < 3 months ago) or wish to become pregnant during the study
Office systolic blood pressure > 160 mmHg and/ or diastolic blood pressure > 95 mmHg, irregular heart rate and/or heart rate > 100 bpm. Eligibility of subjects with a heart rate <56 bpm will be assessed by the research physician
Not able to perform the computer tasks assessed during screening
Reported participation in night shift work during the study period
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Explicit and implicit mood<br /><br>Concentration and attention</p><br>
- Secondary Outcome Measures
Name Time Method <p>Blood pressure<br /><br>Personality scores</p><br>